1245 results
To determine whether (supplemental) human donor milk has beneficial effects (in terms of reduction of infectious episodes and mortality) when compared to (supplemental) preterm formula during the first 10 days of life in VLBW infants. Amendement ESS…
To determine if orteronel plus prednisone improves radiographic progression-freesurvival (rPFS)To determine if orteronel plus prednisone improves overall survival (OS)
Subjects randomized to the placebo treatment are unlikely to benefit from the study. However, OAB is not a life-threatening disease and it is not expected that a 12 to 15 week exposure to placebo treatment will have a negative impact on disease…
The primary objective of this study is to compare the efficacy of eprotirome 50 microgram and eprotirome 100 micorgram versus placebo in terms of the percent change in LDL-C from baseline to Week 12 in HeFH patients with CAD, or who are at high risk…
The primary objective of the study is to examine the changes in core body temperature during a 60 minute cycling exercise bout at 85% of maximum predicted heart rate using double blind placebo or paracetamol in a group of healthy young subjects.
Trafermin spray is a new treatment that is being studied in wound healing and particularly for the treatment of diabetic foot ulcers. When trafermin is sprayed onto a wound, it stimulates the skin and blood vessels to grow again and so speeds up the…
To determine non inferiority of two doses of BI 10773 (10 mg/daily and 25 mg/daily) compared to placebo with respect to first occurrence of any of the adjudicated components of the primary composite Major Adverse Cardiovascular Event endpoint (…
1. Primary objective:To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in subjects aged 18 years and older with chronic non-cancer pain, suffering from OIC.2. Secondary objectives:To assess the safety and…
To replicate and extend the findings of the recent methylphenidate study in which methylphenidate was found to enhance episodic memory performance; To explore whether this effect of methylphenidate is primarily mediated by its dopaminergic action.
Given the medical need for improved treatment strategies for patients with previously treated and relapsed MM, the purpose of this phase III study is to compare treatment with bortezomib/dexamethasone + panobinostat to bortezomib/dexamethasone +…
Primary Objective: to ascertain whether administered clonidine and scopolamine affect performance (as measured by modulation of reaction times, learning and/or error rates) in a range of cognitive tasks designed to examine uncertainty estimation and…
To find a simple test to explain non-responsiveness to sumatriptan in a proportion of patients with migraine.
The objective of this study is to investigate the added effect of an intramuscular (IM) gluteal corticosteroid injection above a placebo IM gluteal injection (saline) on pain symptoms in patients with hip OA, not responding satisfactory to the usual…
Driven by the hypothesis that combination of dietary polyphenols, with distinct mechanisms of action, may improve cellular energy and fatty acid metabolism, preventing thereby the development of the metabolic syndrome and diabetes, the following…
To compare the therapeutic benefit of maintenance pazopanib versus placebo after first line treatment of NSCLC.
To study whether pretreatment with metformin can reduce myocardial injury during CABG surgery in patients without diabetes mellitus.
In the proposed study, two main issues will be addressed: first, it will be studied whether a high dose (4.0 mg) of FA supplementation periconceptional has an added value over the now recommended low dose of 0.4 mg in the prevention of congenital…
1) Safety: Non inferiority of the BioFreedom* to the Gazelle* Bare Metal Stent in patients treated with one month DAPT only followed by aspirin alone. The non-inferiority will be assessed by the composite endpoint of CD, MI and ST at 1 year.2)…
The primary research inquiry being raised concerns anaesthesia related causes:Is it possible that adapting an amount of sevoflurane, from 1 MAC (minimum alveolar concentration) (2,5 vol%) to * MAC (1,25 vol%) in an MRI scan can reduce the frequency…