384 results
To assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an Alzheimer*s disease-causing mutation by determining if treatment with the study drug slows the rate of progression…
Aim of this pilot study is to determine which intervention groups are feasible in a larger trial which aims to a compare postoperative pain and complication rates in moderate versus deep neuromuscular blockade, and normal versus low intra-abdominal…
The main objective of this study is to investigate the effect of cerebellar tDCS on impulsivity in healthy adults.
To study the effect size of FMT after a 3 weeks course of budesonide as induction therapy in patients with active ulcerative colitis despite previous therapy. The purpose of the pre-treatment is to reduce active inflammation prior to donor feces…
We hypothesize that ingestion of potato protein increases muscle protein synthesis rates at rest as well as during recovery from exercise in young healthy males. We hypothesize that the muscle protein synthetic response to the ingestion of potato…
NEDERLANDS Samenvattend onderzoekt dit project de klinische effectiviteit en bruikbaarheid van een nieuwe interventie voor het verbeteren van ziekte-inzicht die wordt ingezet vanaf de start van de (poli)klinische cognitieve revalidatie van patiënten…
To determine the safety and tolerability and to assess the PK and performance of VB5-845D-800CW in healthy volunteers and patients
RTX 1*1000 mg compared to a placebo controlled group leads to a higher proportion of patients in glucocorticoid remission at week 21 in newly diagnosed PMR patients fulfilling the Chuang-criteria
1) There will be an effect of anodal stimulation to the left STG with reduced response bias on the signal detection task 2) This effect is specific for speech signal detection.
We expect that treatment with azelastine/fluticasone propionate will decrease exercise tolerance limitation and will improve quality of life.
Ghrelin administration in comatose patients after cardiac arrest is safe, causes no serious adverse events relatable to ghrelin use and it improves functional recovery in these patients.
Crohn’s disease (CD) is a chronic inflammatory bowel disorder (IBD) with a major impact on quality of life. Mucosal healing is an important treatment outcome to prevent long term complications of the disease. Regulatory M2 type macrophages play a…
Saphenus blok reduceerd opname duur na epifysiodese van de knie - een triple blind superiority trial
We hypothesize that a single shot saphenous nerve block in combination with general anesthesia would be superior to general anesthesia alone regarding opiod consumption. pain scores. recovery and length of stay in adolecent patients undergoing…
We hypothesize that endurance athletes receiving protein supplementation report a lower delayed onset muscle soreness score and lower muscle damage biomarker concentrations post-exercise compared to athletes receiving placebo supplementation.
Respiratory Syncytial Virus (RSV) is still the leading cause of hospitalization of children under 5 years of age. Currently, there is no effective treatment licensed for an ongoing RSV infection. Therefore, Intravacc develops a live-attenuated…
We hypothesize that UDCA on top of ezetimibe leads to an increased cholesterol excretion via the feces by stimulating ABCG5/8 and preventing absorption of cholesterol due to blocking NPC1L1 and therefore promoting elimination of cholesterol from the…
Spinocerebellar ataxia type 3 (SCA3) is the most common subtype among the autosomal dominant cerebellar ataxias, a group of debilitating, progressive conditions for which currently no disease-specific treatment ¨C i.e. aimed at the underlying…
Deep brain stimulation (DBS) targeted at the ventral anterior limb of the internal capsule (vALIC) is an effective treatment for treatment-refractory obsessive-compulsive disorder (OCD). However, effective DBS for these patients requires relative…
De zoete inval: zijn versuikerde eiwitten in voeding betrokken bij het ontstaan van type 2 diabetes?
Consumption of meals with a low advanced glycation endproduct content versus high advanced glycation endproduct content improves insulin sensitivity
The ingestion of free amino acids will result in higher plasma amino acid concentrations, resulting in enhanced muscle protein synthesis rates when compared with the ingestion of milk.