8 results
Primary Objective(s):1. To determine whether aging associated cognitive impairment can be attenuated by roflumilast administration as assessed by cognitive battery tests.Secondary Objective(s):1. To determine whether brain electrical activity (ie,…
The primary objective is to examine whether roflumilast (a PDE-4 inhibitor) can improve the cognition of healthy young volunteers. Secondary, we will assess the effects of roflumilast on electrophysiological correlates of cognition.
To assess impact of high doses vitamin D on tumour histology in breast cancer patients
* To investigate the effect of roflumilast 500 µg tablets once daily versus placebo on exacerbation rate, and pulmonary function and major adverse cardiovascular events (MACE) in COPD patients who are concomitantly treated with a fixed combination…
The main aim of this study is to assess hypothesis A, and we will perform an exploratory analysis on hypothesis B.
To assess the effect of vitamin D supplementation on exacerbation rate in patients with COPD and a vitamin D deficiency.
The aim of this study is to examine whether roflumilast improves cognition in clinical patients with MCI or mild dementia.
The objective is to validate the effects of chronic roflumilast treatment on cognitive function (i.e. episodic memory) by means of behavioral tasks, in people suffering from cognitive impairments at least 1 year after stroke.