9 results
To evaluate the efficacy of 400 mg QD hydroxychloroquine in hand OA patients after 24 weeks of treatment.
The aim of the study is to investigate the effects of atomoxetine on driving performance compared to placebo in 30 adult patients with ADHD. An auditory oddball paradigm will be presented and EEG will be measured during driving to gain insight in…
• To elucidate the role of noradrenaline in the mechanisms involved in human memory consolidation• Evaluate the levels of cortisol and 3-methoxy-4-hydroxyphenylglycol in the various points of a memory consolidation window• Define pharmacological…
The objective of this study is to assess the efficacy and safety of radium-223 dichloride in subjects with human epidermal growth factor receptor 2 negative (HER2 negative), hormone receptor positive breast cancer with bone metastases treated with…
In a clinical trial it will be investigated to what extent combination therapy with LEF and HCQ will 1) inhibit disease activity, in particular improvement of ESSDAI and dryness and 2) inhibit activity of (autoreactive) B-cells, T-cells and pDCs. In…
This study is designed to assess the antiviral activity of hydroxychloroquine in patients with SARS-CoV-2 virus. To evaluate the antiviral effects of hydroxychloroquine at the earliest stages of disease, the study will be conducted in outpatient…
to provide access to Radium-223 dichloride together with abiraterone and prednisone to patients diagnosed with CRPC with bonemetasasis.
Primary objective:To evaluate the efficacy of each active treatment combination (hydroxychloroquine + leflunomide and hydroxychloroquine + mycophenolate mofetil) based on proportion of responder patients according to preliminary STAR at week 24.…
To assess clinical efficacy and safety of Leflunomide/Hydroxychloroquine in pSS patients in a phase IIb placebo-controlled randomized clinical trial at 24 weeks, followed by a single-arm crossover and an open extension (total duration of 48 weeks)…