3287 results
To determine the difference in secondary caries lesion development in tooth samples with simulated restorations from different restorative materials and to relate this to the microbial composition and acid production capacity of biofilm taken from…
Primary Objective: To evaluate the immunogenicity of N9-GP.Key Secondary Objectives: * To evaluate clinical efficacy of haemostasis (treatment of bleeding episodes) of N9-GP.* To evaluate clinical efficacy of N9-GP in long term bleeding prophylaxis…
To evaluate whether spinal cord stimulation is benificial for chronic heart failure patients
Primary Objective: To assess immediate and long-term effects of Mindfulness-based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) in reducing depressive symptoms in patients with diabetes. Regarding immediate effects, we expect that…
To reduce the extent of healthy breast tissue resection by US-guided surgery for palpable tumours compared to traditional palpation-guided surgery, without compromising oncological principles. To improve cosmetic outcomes and quality of life by US-…
We propose a 2-week randomized controlled, single-blinded pilot study to compare the health effects of a Paleolithic diet and an isocaloric reference diet (based on the *Guidelines for a healthy diet 2006*) on markers of the MetS which are risk…
The primary objective of this study is to demonstrate whether the MiStent Drug Eluting Coronary Stent System can safely and effectively improve coronary luminal diameter in patients with symptomatic ischemic heart disease due to discrete de novo…
The primary objective of this study is to evaluate tolerance of a new high-energy high-protein oral nutritional supplement compared to a commercially available high-energy high-protein oral nutritional supplement in elderly subjects in need of oral…
Primary objective of this study is to improve medication adherence by introduction of adequate screening methods and an additional specific nurse based intervention (structural informative consulting and motivational counseling) in combination with…
We aim to investigate whether pulsatile flow in patients subjected to CPB preserves postoperative microcirculatory perfusion by prevention of a prothrombogenic profile and endothelial activation as are both present under non-pulsatile flow…
The primary objective of this study is to adjust the treatment protocol to specific cognitive problems related to Parkinson's disease and subsequently to evaluate the effectiveness of the protocol. Secundary objective is to get an overview of…
The aim of the study is to test, for the first time, whether physical task persistence in people with chronic pain can be explained by the mood as input model.
The objective of the study is to compare the effects of homogenized, unhomogenized and skimmed milk with butter on postprandial metabolism in healthy overweight men.
Our objective is to evaluate the patency of paclitaxel coated balloons in hemodialysis patients presenting at the radiology department more than once a year with repetitive severe stenoses of their fistula, and compare the results with primary…
The main aim of the present study is i)To assess whether sugammadex has a positive effect on the post-operative alertness of the patients, and ii) to assess the nature, magnitude and the time of onset of this effect (if any).
To determine the effect of a structured diagnostic-therapeutic strategy to detect and treat previously unrecognized or unestablished heart failure in primary care as compared to care as usual.
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Primary objective:To demonstrate that the mean change from baseline in Best Corrected Visual Acuity (BCVA) over a 12 month treatment period obtained with either a 0.5 mg ranibizumab *Treat and Extend* (TE) dosing regimen with adjunctive laser, and/…
Primary objective: To determine if a single dose of SRT2379 attenuates the inflammatory response in normal healthy male subjects after exposure to low-dose endotoxin (LPS) Secondary objectives: (1) To determine PK of SRT2379 in normal healthy male…
Comparison of preoperative diets before bariatric surgery with a randomized non-inferiority trial in order to compare the standard VLCD with a standard diet.