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To determine prospectively the correlation between in vitro patient-derived organoid response and progression-free survival.
We aim to define components which are critical for lysosomal homeostasis and are affected in CLN3 disease. To this end we will perform multi-omics analysis of lysosomes isolated from fresh peripheral white blood mononuclear cells (PBMCs) of…
The primary objective of this study is to determine the safety and feasibility of turbine-based insufflation, measured in terms of occurrence of adverse device effects and serious adverse device effects. The secondary objectives are to determine the…
Primary objectives:- To assess the differences in resting state EEG frequency spectrum analysis between patients with neurodegenerative and patients with non-neurological causes of MCI.* Power in microvolts squared of resting stage EEG for different…
2. OBJECTIVESThe overarching goal of this proposal is to examine the feasibility and effectiveness of mobile-based screening for MDD. We combine validated screening and interventions for MDD with innovative outreach methods to maximize impact.…
To determine whether guided growth of the proximal femur decreases the risk of further hip migration and need for further surgery in cerebral palsy patients.
To evaluate the effect of transcutaneous electrical nerve stimulation (TENS) in patients with ANOCA on the change in the summary score of the Seattle Angina Questionnaire (SS SAQ) after 1 month treatment with TENS, compared to baseline.
To investigate the fluctuation patterns of different pulmonary parameters in patients with severe asthma, before and after starting a treatment with biologics, using daily measurements with the Respicorder device.
This study examines a the role of four key ultra-high-risk criteria for personality disorders: interpersonal trauma, personality functioning, quality of social support system and subclinical features of borderline personality disorder. For two of…
This study aims to evaluate the Corsano Cardiowatch 287-2 for heart rate, heart rate variability (RR intervals), oxygen saturation, respiratory rate, and blood pressure during strenuous activities such as High-Intensity Interval Training (HIIT).…
Demonstrate that the self-expandable Allegra TAVI system provides lower mean gradient assessed by TTE compared to balloon-expandable valve systems in a population of all women patients with symptomatic severe aortic valve stenosis.
The aim of this study is to evaluate the validity of various algorithms for gait bout detection and spatiotemporal measures with a 3-IMU based sensor set worn on the feet and lower back. If this algorithm can be validated, it can be used to obtain…
We aim to investigate language production and verbal episodic memory performance, as well as the respective associated neural (co-)organisation of the two systems observed post-surgery in people with left temporal epilepsy in comparison to healthy…
Primary Objective: To further develop and evaluate a personalised patient-centred surveillance programme including a feedback platform for patients after curative treatment for CRC in terms of health-related quality of life (HRQoL).The goal is for…
This study will provide insights into the role of gut microbes from the upper (saliva) and/or lower GI (rectal/faecal) microbiota in the occurrence of postoperative complications in patients with resectable pancreatic and periampullary presumed (pre…
The objective of this study is to evaluate the safety and effectiveness of the PerQseal Elite vascular closure system when used to achieve haemostasis of common femoral venotomies created by 14 to 22F sheaths (venotomy up to 26F) in patients…
This study aims to provide insights into the processes and key host immune and microbiota factors that determine the infection kinetics, transmission and development of immunity during such infections. Furthermore, this study will enable us to…
The primary goal of this study is to evaluate the effectiveness of VR-exposure therapy (VRET) in diminishing anxiety and avoidance within adolescents with social anxiety. We expect that, compared to the within-person baseline and standard treatment…
The primary aims of this study are therefore to 1) compare DmO2 derived via NIRS between young sedentary, young endurance-trained, older sedentary, and older endurance-trained subjects; 2) to compare non-invasive (i.e. with NIRS and 31phosphorous…
To investigate whether implementation of a best practice program for preoperative optimisation of patients with a focus on screening, assessment, and intervention of 8 potentially (partly) modifiable risk factors (low (aerobic) fitness level,…