720 results
To explore cardiovascular remodelling with subsequent altered cardiac function (assessed as strain rate) in extremely premature neonates (born <30 weeks and/or birth weight < 1000 gram) with FGR.
To improve the pathological response rate according to Miller and PayneTo improve quality of life including cognitionTo determine the effect of FMD on local tumor immunity
- special attention for the development and harmonization of the pre-analysis of liquid biopsy, for blood as well as urine, andnext to this for ctDNA- special attention for the detection of PIK3CA mutations in blood and urineSimultaneously also the…
Primary objectives: To evaluate the efficacy of long-term prophylactic treatment with PHA-022121 in preventing breakthrough angioedema attacks in patients with AAE-C1-INH. Secondary objectives: To evaluate the safety of long-term prophylactic…
The objective is to evaluate the extent of lymph node dissection, efficacy, risks, quality of life and cost-effectiveness of RAMIE as an alternative to MIE as treatment for esophageal cancer.
To assess whether minimally invasive nonsurgical microwave ablation (MWA) followed by postprocedural MRI scan can be an alternative treatment for breast surgery in early stage breast cancer: a non-inferiority study .Is the quality of life, cosmetic…
To test if a CRT-targeted resuscitation based on clinical hemodynamic phenotyping can improve a hierarchical clinical outcome - mortality, time to cessation of vital organ support, and length of hospital stay, all within 28 days - in septic shock…
Determine speech understanding in noise with the AB*s bimodal BF directional hearing technology.
The primary goal of this study is to investigate the effects of belimumab on the composition of lymph nodes and the inflamed synovial tissue as well as (subsets of) immune cells in the peripheral blood. In addition, we will identify immunological…
The objective of this clinical study is to assess the safety and effectiveness of the Apollo Intravascular Lithotripsy (IVL) System for lithotripsy-enhanced balloon dilatation of calcified, stenotic de novo coronary lesions prior to stenting.The…
The present study proposes to investigate the On(t)schuldig intervention. The main research question: Do adolescents report less trauma-related feelings of shame and guilt after following the intervention On(t)schuldig?
As highlighted, significant gaps in knowledge remain regarding etiology of cough, consequences of cough and appropriate treatment of cough in patients with pulmonary fibrosis. A further understanding of the similarities and differences in cough…
Primary Objective: The feasibility of injecting 99mTc-nanocolloid via a flexible laryngoscope with a working channel and subsequent detection of SLN will be evaluated.Secondary Objective: Preoperative located SLN via gamma camera imaging will be…
• The primary objective is to demonstrate non-inferiority of the detection rate of clinically significant prostate cancer (defined as GG >= 2) in targeted biopsies based on PCaVision imaging (PCaVision pathway) in comparison with the…
This study aims to determine the effect of nocturnal versus daytime cyclic infusion of parenteral nutrition in adult chronic intestinal failure patients on bone turnover, glucose metabolism, nitrogen balance, sleep and wake rhythm and clock genes…
This study is aimed at investigating the effect of imagery rescripting on selfreported low self-esteem in personality disorders and the effect on diverse complaints (anxiety, depression), wellbeing and core cognitions. This might be a step into…
The aim of this study is to assess the clinical value of bedside tests compared to DUS to detect PAD in patients with diabetes-related foot ulceration, with special emphasis on the ACCmax.
To determine the feasibility (main aim) and effectiveness (secondary aim) of a prehabilitation program in patients with HNC or liver cancer
To identify molecular biomarker profiles that are associated with cervical tumorigenesis, and that can be used for development of an algorithm for detection of low grade CIN1, CIN2, CIN3 and cervical cancer. The algorithm should provide advice for a…
Primary Objective: Compare Atellica VTLi Sepsis biomarker values from capillary whole blood from fingerstick with anticoagulated whole blood and plasma from venipuncture.Secondary Objectives: Correlate the blood and plasma outcomes on the Atellica…