141 results
The aim of this proposal is threefold: (i) test a neuroscientific model of prosocial development by relating neuroscience discoveries to changes in several dimensions of prosocial development in a comprehensive study including children, adolescents…
In this study, the aim is to perform a clinical evaluation of the NovioMini in children during behavioural bladder training to examine the performance of the NovioMini as a full-bladder-based notification system during natural bladder filling.
To establish a healthy control group for microcirculatory parameters for current and future studies on the paediatric microcirculation.
Objectives: 1) to evaluate the effectiveness of the e-CBT-i “i-Sleep” compared to a waiting list condition on sleep efficiency at 3, 6 and 12 months in ACC. 2) to assess the effects of eCBT-I on secondary outcomes: fatigue, quality of life, chronic…
Primary objective:To determine the MTD/recommended dose for further study of oral LOXO-292 in patients with advanced solid tumors, including RET-fusion NSCLC, MTC, and other tumors with increased RET activity.Secondary objectives:* To determine the…
Primary safety objective: To evaluate the safety of systemic intravenous administration of the Investigational Medicinal Product (IMP) in pediatric and adult MPS VI patients.Primary efficacy objective: To investigate the efficacy of the IMP through…
Primary Objective: the primary objective of this study is to investigate the accuracy and reliability of coronal curve ultrasound measurements in patients with scoliosis as well as the accuracy and reliability of ultrasound imaging to detect…
Primary objective:Non-invasively determining the 11C-erlotinib brain uptake in DIPG patients by PET imaging.Secondary objective:Determining the EGFR expression in DIPG
Specific Aim #1: To evaluate the efficacy and safety of shortened-duration (6 weeks total) versus conventional duration (3 months total) anticoagulation for first-episode, provoked, acute venous thrombosis among children in whom thrombus resolution/…
The primary objective of this study is to describe the intracardiac anatomy and hemodynamics of DILV patients without Fontan circulation using 4D MRI. Furthermore, the functional status and quality of life of these patients will be assessed and…
The overall aim of this study is to identify developmental deficits in children with Rolandic epilepsy. If developmental deficits are observed, we hope to determine timing, persistence, and prognostic factors for developmental deficits and improve…
1.3. Study Design Rationale The ATLAS-PPX trial (ALN-AT3SC-009) is a multicenter, multinational, open-label Phase 3 switching study designed to demonstrate the efficacy and safety of fitusiran in patients with hemophilia A or B, with inhibitory…
The purpose of the overall project is to adapt an existing self management tool for adults to the needs of young people and how to implement the adapted app within the youth mental health. The overall project consists of three different phases with…
Objective: The present protocol is nested in the TRACE study (CMO 2014-1349, NL50015.091.14 and in the linked TRACE-BIOME study, CMO 2015-1806, NL53630.091.15), and explores whether an ED, compared to healthy diet, affects the fronto-striatal and…
To evaluate the natural progression of disease over time in USH1B patients using visual field testing and best corrected visual acuity.
To investigate whether age-related differences in grammar acquisition primarily reflect maturational changes in neural plasticity and pathways that support learning and consolidating of new linguistic knowledge and skills.
The primary objective of the study is to descriptively characterize the single-dose and steadystatePharmacokinetics (PK) of diacerein (if quantifiable) and its active metabolite, rhein, after topical application of CCP-020 (diacerein 1% ointment)…
To determine the minimal amount of energy needed to effectively terminate ventricular arrhythmias
The goal of the present research is to test the effectiveness of an interactive virtual reality intervention for children with agression problems. Moreover, it is expected that (1) the VR-intervention will decrease aggressive behavior problems, (2)…
Do neonatal critically ill children aged 9-16 years have problems with visuomotor integration? If yes, which aspects of the visuomotor integration are affected and require a possible intervention?