3503 results
there exist intra & inter patient variability of 17β-HSD-1 and other enzymes involved in the local generation of estrogens
Obtain insight into the (difference in) pertussis-specific immunoglobulin G (IgG) levels in the first three months of life between infants whose mothers received a pertussis vaccine (Boostrix) during pregnancy in comparison to infants whose mothers…
Primary Objective: • To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors. In other words, the aim is to investigate whether a more optimal…
We expect that the development of mitochondrial dysfunction lags behind the development of the hypermetabolic inflammatory state. Additionally, we hypothesize that the aggravation of factors related to the hypermetabolic inflammatory status, such as…
Tones vs. neutral self-voice (EEG experiment 1 in Session 3; Pinheiro et al., 2018): a) no effect of HP on N100 suppression for self- and externally generated tones as we would expect alterations in sensory feedback only with regards to one’s own…
To assess the involvement of a specific genetic risk allele on oxidative stress induced by neutrophils in relation to H. pylori infection.
W want to investigate the influence of a mutaion in the MH allel on the HPV and the normal reaction of MH patients to hypoxia
To assess the effect of fitness training on movement efficiency, fitness level, physical activity and quality of sleep in ageing subjects
To determine the relationship between phenotypic, genetic and biochemical features of AD. , Relevant bimarkers of the skin barrier function including the levels of NMFs, inflammatory mediators (e.g. IL-1 cytokines), SC lipids and serine proteases…
To study the extent of impaired urinary concentrating ability in hypothyroidism as well as the pathophysiological mechanisms involved before and after adequate treatment.
Our objective is to perturb neural activity in the parietal-occipital cortex in PD patients (and age-matched control subjects) to determine if the activity contributes to better visually-guided behaviour, but at the same time, to diminished…
The proposed study has 2 main aims: 1) Understanding the complex interplay of determinants of parenting and examining how specific parenting styles explain associations between parent characteristics (such as personality or mental and physical (ill…
To investigate whether in obese subjects meal timing during a hypocaloric diet is related to the brain serotonergic system and insulin sensitivity as well as to food-motivated behavior.
The objective of the study is to map in a standardized way the phenotype of carriers with known LHON mutations. We want to study the natural course of persons with LHON mutations by examining patients several times. Further, we want to study a…
to investigate whether the levels of a panel of biomarkers in dried blood spots can be used as a disease severity measurement tool in patients with AD, treated with topical steroids.
The primary objective of this study is to investigate the effect of hypoglycemia on brain lactate accumulation and regional cerebral blood perfusion in humans. The secondary objective is to assess whether this effect is a related to hypoglycemia…
1. Clinical characterisation of manifestations of aging in the affected individual.2. Understanding of the molecular and cellular mechanisms leading to the manifestations in this affected individual.
The main goals of this study1) To determine the prevalence of BE among first degree relatives of index patients in families that fulfil criteria for familial BE/adenocarcinoma of the GEJ2) Collect tissues of the index patients and all first degree…
The primary objective is to identify (epi)genetic and environmental disease modifying factors that contribute to the variable clinical phenotype of FSHD, in order to support the future development of new treatment strategies for FSHD. The secondary…
To investigate the effect of elevated levels of endogenous lactate on brain lactate accumulation and on counterregulatory responses to, symptomatic awareness of and cognitive function during hypoglycemia in patients with T1DM with and without…