6 results
The primary purpose of this study is to investigate whether immediate implant placement, in ideal position, might preserve soft and hard tissue shape and contours, avoiding the need for extended augmentation and as a result achieving better esthetic…
Primary Objective: To compare peri-implant hard and soft tissue changes as measured on standardized intraoral radiographs and direct digital intraoral scans between the group of single final and and the group of multiple repeated abutment dis/re-…
To determine the maximum tolerable dose of the combination therapy of weekly carboplatin with the Wee-1 inhibitor AZD1775Secondary:To determine the pharmacokinetics of the combination therapy of weekly carboplatin combined with AZD1775To investigate…
Based on results from a comparative review (Paoletti 2013), we hypothesize that if the toxicity profile and the PK parameters observed in children treated at the adult RP2D are similar to those in adults; escalating to the MTD is not necessarily…
The main objectives are:• To assess canagliflozin target (i.e. receptor) specific binding in vivo• To assess receptor occupancy of canagliflozin in vivo• To determine optimal scanning time in vivoTo explore the relationship between canagliflozin…
Objective of the phase II POP study:To determine the safety and preliminary anti-tumor activity of AZD1775 in combination with carboplatin in p53 mutated epithelial ovarian cancer in a 21 day schedule.Objectives of the additional safety and…