10 results
The primary objective is to assess safety and efficacy of abiraterone acetate plus prednisone and abiraterone acetate plus prednisone plus exemestane, each compared with exemestane alone, in postmenopausal women with ER+ metastatic breast cancer…
Primary Objective:To compare the clinical benefit of abiraterone acetate plus prednisone versus placebo plus prednisone in patients with chemotherapy-naïve castration-resistant prostate cancer (CRPC) who are asymptomatic or mildly symptomatic.…
Primary• To evaluate the safety of using a modified staged treatment algorithm at 3*months following the second placement of AeriSeal foam treatment in subjects with severe emphysema.Secondary• To evaluate lung function, exercise tolerance and,…
The purpose of this study is to find out how well JNJ-56021927 works when it is given along with abiraterone acetate and prednisone to treat prostate cancer. The safety of JNJ-56021927 when used with abiraterone acetate will also be studied. How…
Primary:1) Feasibility: Evidence of targeted lung volume reduction (TLVR) on CT scan at 6 weeks and 3 months follow up after endobronchial valve placement.Secondary:2) Safety: The number and type of procedure-related (Serious) Adverse events within…
Primary objective To investigate the safety and tolerability of CCS1477 as monotherapy and in combination.
Determining the effect of chemodenervation by lidocaine of the m. vastus intermedius and the m. rectus femoris in stroke patients presenting with stiff knee gait.
The disappearance of the main symptoms of the COVID*19*induced pneumonia within 5 days after the initiation&…
Part 1In Part 1 of the study, no study compound will be administered, but a bone marrow aspiration and a blood sample will be taken to evaluate an assay that will be used for Part 2 and Part 3 of the study. Because no nirogacestat is given, we can…
Primary Objectives:- To determine the BE of a RS FDC tablet formulation of niraparib and Abiraterone Acetate with respect to niraparib and Abiraterone Acetate co-administered as single agents at steady state under modified fasted conditions in…