3 results
In this single centre pilot intervention study, we will investigate the effects of short-term administration of the angiotensin-receptor antagonist losartan on insulin sensitivity (assessed by using the homeostasis model assessment of insulin…
1. The effect of Losartan on the joint excursions and the Hardening of the skin in a patient with SSS.2. Gain insight in the pathogenesis of SSS3. Gain insight in the functional effect of Losartan in SSS.
Main objective: To investigate whether spironolactone can favourably alter extra-cellular matrix remodelling, assessed by changes in the fibrosis biomarker Procollagen Type III N-Terminal Peptide (PIIINP), in patients at increased risk of developing…