32845 results
Main objectiveTo investigate whether dopamine affects the ability to initiate the correct step in response to a sudden change (improbable picture in a predictable context) in PD with and without FOG. Secondary objectiveTo investigate whether…
Primary Objective: To study whether CSWI+PCA provides similar analgesia after laparotomies for HPB conditions as compared to PCEA measured as the OBAS score, a composite endpoint composed of pain score, patient satisfaction and opioid related side…
Primary:To assess the non-inferiority of the sedative properties of continuous intravenous (i.v.) clonidine compared to continuous i.v. midazolam in mechanically ventilated children and adolescents (0 - <18 years) admitted to a paediatric…
Primary objectiveIs RRSO at age <= 45 in BRCA1/2 mutation carriers a risk factor for development of subclinical atherosclerosis, independent of traditional cardiovascular risk factors? Secondary objectiveAre menopausal symptoms in BRCA1/2…
To explore the dynamic changes in the microbiological composition (of the separate niches) of the oral ecosystem upon refraining from oral hygiene for two weeks compared to baseline and after a one-week resolution phase assessed with or without the…
Considering the background information given in the previous paragraph, the following research question has been formulated:What is the long-term (24 weeks) effect of magnesium citrate (total daily dose: 350 mg elemental magnesium) on vascular…
Main: Investigate the cyclic variation in clot lysis time in women with HMB in comparison to controls. Secondary:- Investigate the cyclic variation in TAFI, PAI-1, tPA, PI, thrombin generation, fibrinogen, fibrin clot permeability and confocal…
The primary objective of this pilot study is to determine the prevalence of (symptomatic) hypoglycaemia (<3.0 mmol/L of at least 15 minutes) in well-controlled (HbA1c <58 mmol/mol) frail elderly patients (>70 years) with type 2…
To assess the efficacy, evaluate the safety and immunological effect of topical 5% imiquimod cream for vulvar Paget*s disease and the quality of life during treatment.
With this study we aim to determine the feasibility of Smooth Seton placement in patients with perianal fistulas
The objective of this project is to investigate uptake, usability and acceptability of two hiv prevention interventions. These relate to the use of biomedical interventions, ie the provision of daily and intermittent PrEP to men who have sex with…
The primary study objective is to assess whether CML patients who respond to treatment with nilotinib (MMR within 12 months of treatment) differ from the non-responders in terms of adherence. Secondary objective is to evaluate whether responders and…
Main objective: To investigate Differences in sustainability of inhalation technique of Diskus® and Autohaler® in the home situation. This will be measured with the inhalation checklist for the Diskus® and Autohaler®. Secondary objectives: * To…
Primary Study Objective: To evaluate the effect of telotristat etiprate versus placebo over the double-blind portion of the study on the incidence of treatment-emergent adverse events (TEAEs)
Primary:The primary objective of this study is to determine whether DMF taken over 12 months is effective in reducing MS-related fatigue, as measured by mean changes in the Fatigue Scale for Motor and Cognitive Functions (FSMC), in subjects with…
Objective 1: To investigate the difference in prescribing proton pump inhibitors continuously rather than on demand in patient reported reflux symptoms, quality of life and self-rated health. Objective 2: To investigate whether the use of electronic…
We aim to to record heart rate patterns during seizures with miniaturized wearable EKG-monitors in a large cohort of DS
To investigate whether a 200 mg bid fixed dosage regimen of ciprofloxacin achieves concentrations associated with maximal efficacy and minimal spread of resistance in ICU patients undergoing CVVHD.
Primary ObjectiveTo assess the effect of ABT-981 on OA knee pain using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at Week 16 and synovitis/effusion volume of the index knee using quantitative measures and semi-…
Primary objective:To gather information on the feasibility of a prospective, international multicenter study in which, on the basis of biomarker-based risk stratification, patients at high risk for progression are randomized to radiofrequency…