21 results
1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10. This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1…
Continuous Intrajejunal Levodopa Infusion is not cost-effective compared to Deep Brain Stimulation
Primary objectives: - Overall: Improvement of event-free survival (EFS) probabilities in childhood relapsed ALL - Randomization 1: EFS of Arm A (ALL-REZ BFM 2002) versus B (ALLR3) in SR patients - Randomization 2: Influence of epratuzumab…
The objective was to assess the effectiveness of low-dose aspirin in the prevention of recurrent preterm birth.
We hypothesize that the T2T strategy is superior compared to the T2S in retaining gout remission and is also more cost-effective.
To investigate the pharmacokinetic profile of magistrally compounded CDCA capsules.
We hypothesise that antibiotic-corticosteroid eardrops are non-inferior to oral antibiotics in resolving ear pain and fever at day 3 (72 hours after randomisation) in children aged 6 months to 12 years visiting their GP with AOMd and either ear pain…
The effect of mebeverine on abdominal pain intensity and frequency in children with irritable bowel syndrome or functional abdominal pain – not otherwise specified will be effective.
Postoperative recurrence of CD (Crohn's disease) is very common in patients having undergone bowel resection, and often leads to further bowel resection. Postoperative recurrence is frustrating to both the physician and patient, and thus an…
To determine the musculoskeletal safety of standard prophylactic treatment with ciprofloxacin and co-administered glucocorticoids in pediatric patients with acute lymphoblastic leukemia (ALL).
To investigate whether Envarsus® leads to a significant reduction in new onset diabetes, chronic kidney disease and new onset hypertension.
In patients with recently diagnosed PMR, MTX 25mg/week compared to placebo will lead to a higher proportion of patients in glucocorticoid free remission
To investigate the effect of various dietary interventions and co-administration of subcutaneous semaglutide on the pharmacokinetics of alectinib in NSCLC patients.
IV sildenafil is superior to iNO for the treatment of pulmonary hypertension in CDH newborns and should be considered as the drug of first choice in the future
Postoperative NRS pain scores in the breast after BCS are lower in women who receive a preoperative PECS II block than in women who receive a sham block.
Major burns encompassing more than 15-20% of total body surface area (TBSA) induce a pathophysiological stress response and thereby massive inflammatory response. Patients with major burns develop metabolic changes and burn induced hypermetabolism,…
Semi-annual treatment with zoledronic acid reduces both pain and progression of structural damage in knee osteoarthritis patients with MRI-observed bone marrow lesions
Local antimycotic treatment of fungal toenail infection is more effective than placebo
Treatment with Venoruton prevents RVO, which is a surrogate outcome of PTS.