28 results
To prospectively study if patients carrying clinically relevant DPYD variants (DPYD*2A, c.2846A>T, c.1236G>A/HapB3, c.1679T>G) are more at risk for developing moderate/severe vesicles or bullae with 5-FU cream.
The different processing of formulas will have an effect on stool characteristics such as consistency, frequency, amount and colour.
there exist intra & inter patient variability of 17β-HSD-1 and other enzymes involved in the local generation of estrogens
We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…
Adequate perfusion of an adult-sized renal graft in children demands significant hemodynamic changes after transplantation (Tx). Suboptimal renal graft perfusion due to inadequate hemodynamic adaptation increases the risk of loss of renal graft mass…
Objective The objective of this study is to assess which risk scoring model is most cost-effective for the discrimination between benign and malignant ovarian tumors that guides referral decisions for women with ovarian tumors in the Netherlands…
HFpEF patients have impaired peripheral microvascular function compared to controls without HFpEF, with correction for important confounders of microvascular function.
Objective: The primary objective of the study is determining the contributing factors in bracing for AIS. The contributing factors are determined as factors of influence in the corrective possibilities and therefore end term…
PENG block with phenol provides better pain relieve and mobility, and therefore quality of life, compared to current pain relieve strategies in patients with a hipfracture who are not eligible for surgery
Tones vs. neutral self-voice (EEG experiment 1 in Session 3; Pinheiro et al., 2018): a) no effect of HP on N100 suppression for self- and externally generated tones as we would expect alterations in sensory feedback only with regards to one’s own…
We hypothezise that patients with a primary tumor expressing ER and lacking HER2 but with CTCs expressing HER2 have a worse response on hormonal therapy.
Action research in which the intervention will be developped trough short-cylce evaluation rounds by the research team together with an expert panel. The initital intervention has been designed based on scientific literature review, practical…
Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals
paracetamol can be used to determine plasma volume
Bone-anchored maxillary protraction therapy improves facial profile in cleft children.
Circulating miRNAs can be easily measured in body fluids which, in case of nipple fluid, could offer a promising minimally invasive method to complement current breast cancer screening methods, especially for high-risk women. In this study we aim to…
The primary objective is to measure the effect of nociceptive stimuli on features derived from ECG, ABP, PPG, EEG and facial video recordings, to be used to design an index of nociception. The index of nociception should correlate well with strength…
To analyze the number of patients with (germline/somatic) actionable molecular aberrations in patients with relapsed/refractory pediatric tumors for whom no standard treatment or study protocol is available.
Our hypothesis is that macrophages drive ANCA glomerulonephritis by activating T-cells and enhancing their migration towards vasculitic inflammation. Permanent macrophage activation could contribute to chronic elevation of fatigue levels.