42 results
there exist intra & inter patient variability of 17β-HSD-1 and other enzymes involved in the local generation of estrogens
We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…
The different processing of formulas will have an effect on stool characteristics such as consistency, frequency, amount and colour.
Critical illness, along with the lack of zeitgebers on the PICU environment, and iatrogenic influences like medication and procedures, results in disturbed circadian rhythms in critically ill children, which is important for their recovery.
To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…
Adequate perfusion of an adult-sized renal graft in children demands significant hemodynamic changes after transplantation (Tx). Suboptimal renal graft perfusion due to inadequate hemodynamic adaptation increases the risk of loss of renal graft mass…
We hypothesize that telemonitoring through SpA-Net, in combination with patient-initiated care, will lead to less outpatient visits, without compromising quality of care and health outcomes. Furthermore, we expect that telemonitoring through SpA-Net…
Our primary objective is to compare the effectiveness of NACD and ESWT for patients with calcifying tendinitis of the shoulder. Our hypothesis is superiority of NACD or ESWT above the other treatment in functional recovery over a period of 12 months…
To determine the content validity and clinical utility of the Dutch sPCI according to nurses with expertise in stroke care and stroke patients, respectively.
Irregular heart rate can be detected with a camera-based monitoring technology.
We hypothezise that patients with a primary tumor expressing ER and lacking HER2 but with CTCs expressing HER2 have a worse response on hormonal therapy.
MelanoScan
The aim of this study is to identify barriers and facilitators for successful implementation of the care pathway, to ultimately inform national scale-up of the pathway.
In the current study, biomarkers for tumor and immune response during radium-223 are evaluated, thereby potentially contributing to a better understanding of immune responses during radium-223 and the rational design of future treatment strategies…
Transcutaneous pulsed radiofrequency (tPRF) may affect tumor activities.
This study will investigate the potential value of CFX treatment, by prospective monitoring of functioning in patients that undergo this treatment. Likewise, aspects of the treatment that are important for patient experience will be systematically…
The hypothesis investigated is that a correct diagnosis (including subclassification of the tumor) and prognosis can be made more rapidly and that monitoring tumor development in response to therapy is more precise when adding tumor markers to the…
This research aims to determine factors involved in subfertility and serious pregnancy complications that arise early in pregnancy. Due to increased insight into the pathogenesis of these conditions, primary prevention should ultimately be possible.
The primary aim of this split-mouth randomized clinical trial is to assess accuracy of bracket positioning of a fully digital IDB workflow compared to a DBB workflow, with IDB bracket planning serving as reference for both methods. The secondary…