390 results
The first objective of the study is to predict the prevalence of PH in sarcoidosis with pulmonary involvement, and to optimize the diagnostic approach in screening for PH associated sarcoidosis using the RHC as gold standard (Galie, 2009). The…
Investigate the phenotype, function and regulation of TRM in healthy human lung tissue, lung tumors and peripheral blood to improve the understanding of respiratory diseases and adoptive T-cell therapy for lung cancer.
The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…
Primary objective: to evaluate the image quality between the two protocols using Signal to Noise Ratio (SNR) measurements Secondary objectives: 1) test if measurements of lung volume and central airways dimensions using MRI are related to validated…
The first objective of this study is to evaluate by direct laryngo-tracheoscopy the possible role of cuffed versus uncuffed tracheal tubes in producing airway injury in infants and children who were previously more than 24 hours intubated. The…
Primary objective: the assessment of the maximal mean lung dose that is accepted to safely treat large peripheral tumors or 2 lung metastases simultaneously using SBRT. Secondary objectives:- evaluation of local control - evaluation of regional…
Primary objective:To compare the change in small airways obstruction (FEF75%) in patients with CF when inhaling one ampule of inhaled tobramycin with the Akita® compared to standard of treatment (twice daily nebulization of one ampule using standard…
Objective: to obtain lung function parameters in infants born preterm at the age of 6 months and to evaluate risk factors for impaired lung function
To determine the effect of bubbling therapy on asthma control in patients with difficult to treat asthma and dysfunctional breathing.
To evaluate the effect and feasability of a short support program for patients with IPF and their partners. The secondary objective is to explore if hair cortisol, as a measure of chronic stress, is a feasible biomarker for Quality of Life in IPF.
The primary aim of this observational study is to determine the occurrence of (exercise-induced) pulmonary hypertension (sPAP > 40 mmHg) in IIP patients with an elevated V*E/V*CO2 at AT (> 34) assessed during CPET. And, secondly to…
To investigate whether enhanced expression of growth factor receptors (FGF-R, PDGF-R and VEGF-R) and increasedvascular cell proliferation in the lung of IPF or PAH patients can be assessed using [11C]-Nintedanib or [18F]-FLTPET/CT imaging.
The purpose of this research project is to improve the overall quality and resolution of the MRI images, to correct for movement effects during the procedure and to speed up the investigation. The goal is to enhance and standardize a technique…
The aim of the basic research in the laboratory is to develop new treatments to repair large bone defects, repair cartilage defects or inhibit the progression of osteoarthritis (cartilage degeneration). We focus on the following questions:1.How can…
The main objective is to investigate the additional value of CRP-POCT (C-reactive protein point-of-care-test) testing in patients suspected of airway infections in long-term care facilities.
To evaluate image quality and accuracy of detection of perfusion defects associated with pulmonary pathology on iodine maps of the lung that are created by two different CT techniques: 1. A standard of care CTPA with DECT and 2. A new technique that…
To evaluate long term safety, efficacy and airway remodelling effects of BT in patients with severe asthma.
This study aims to investigate the process and outcome of the implementation of a coaching intervention in COPD care in the Friesland province.
In this study we would like to find new biomarkers in BOS after haematopoietic stem cell transplantation (HSCT), that may lead to earlier identification of BOS than a lung function decline.
The primary objective of the study is to evaluate the effect of diuretics on right ventricular function and volume properties in patients with symptomatic right heart failure and PH.