121 results
The study objective of the trial was to test the hypothesis that treatment with mepolizumab only affects inflammatory eosinophils whereas treatment with benralizumab affects both inflammatory and resident eosinophils.
PCT-guided treatment regarding antibiotic use is non-inferior to usual care consisting of prednisolone and or antibiotics, in terms of treatment failure at day 30 for patients hospitalized because of an acute exacerbation of COPD (AECOPD).
This study aims to phenotype and endotype bronchiectasis during stable disease and exacerbations, to develop strategies for personalised medicine.3.1 Primary ObjectiveTo determine molecular endotypes of bronchiectasis which can guide response to…
The purpose of this trial is to demonstrate proof of concept of clinical activity of BI 1015550 on the change of Forced Vital Capacity (FVC) between baseline and 12 weeks. New treatments are needed that further reduce the decline in FVC, positively…
The overall aim of this study is to gain experience with the Thermal Vapor treatment by investigating the safety and efficacy of the treatment.Primary Objective: The primary objective is to investigate the change in Lung function (measured by Forced…
The primary objective of this study is to improve asthma control in adults with difficult to treat asthma, by increasing therapy adherence and inhalation technique with qualitative feedback.
In this study we will compare the therapeutic value of nasal saline irrigations only versus nasal saline irrigations combined with nasal application of STB* ointment in patients who received inferior turbinate coblation by radiofrequency (ITC-RF).…
To determine the accuracy of the *NeoBeat* device against gold standard measurements obtained by an ECG monitor with disposable (gel) electrodes and against pulse measured preductally as derived by pulse-oximeter.
To validate our previous findings, and to continue and deepen our exploration of biomarkers in BALF, providing endpoints that correlate with disease progression. We will do this through in-depth cellular and molecular profiling of BALF and blood,…
The primary aim of the study is to get insight in the effects of long-term HI-NIV in severe COPD patients on the respiratory muscles; i.e. the contractile strength and the structure of single diaphragm and intercostal muscle fibres and the lungs; i.…
The purpose of this study is to evaluate the efficacy and safety of DFV890 in addition to current standard of care (SoC) compared with SoC alone in controlling the inflammatory syndrome and resultant acute respiratory distress syndrome (ARDS) in…
-To describe the differences in the parameters of physical exertion during physical activity with two different HMEs in both a lab and daily life setting-To asses patients* satisfaction with both types of HMEs
Primary Objective:To evaluate the efficacy of ELX/TEZ/IVA in subjects 6 through 11 years of age with CF, heterozygous for F508del and a MF mutation (F/MF)Secondary Objectives:• To evaluate the PD of ELX/TEZ/IVA• To evaluate the safety of ELX/TEZ/IVA
To determine the differences in muscular activity of the diaphragm between children with controlled asthma, uncontrolled asthma, dysfunctional breathing patterns and healthy children.
Primary objective* To determine the seroprevalence of SARS-CoV-2 neutralising antibodies in HCWs in Dutch hospitals.Secondary objectivesBaseline, all participants * To determine the seroprevalence of SARS-CoV-2 total antibodies in HCWs in Dutch…
A primary objective of the study is to explore the underlying causes of the excess pneumonia risk in individuals living in the proximity of goat farms. Another objective is to study associations between long-term exposure to livestock farms and…
Primairy objective: Validating of nerve fiber length, nerve fiber density, nerve fiber branches and tortuosity of a healthy control group, sarcoidosis patients with small fiber neuroapthy and sarcoidosis patients without small fiber neuropathy.…
Primary objectives:• to assess the safety of combining nivolumab, ipilimumab and up to 3 fractions of medium dose hypofractionated radiotherapy (mRT) to multiple tumor sites (1 to 4, with at least 1 site receiving 24Gy)• to explore the efficacy of…
The primary objective is to assess the safety and efficacy of the Early@home telemedicine system that relocates hospital care for patients recovering of COVID-19 to the home situation. The secondary objective is to assess the impact of this…
The primary objectives of this study are:· To assess the time to first exacerbation of COPD, measured from the time of randomization The secondary objectives of this study are:· To evaluate the improvement of quality of life by Saint George*s…