121 results
Primary objectives are:1.1) to study the effect of oral administration of morphine SR on health-related quality of life; 1.2) to explore whether morphine SR leads to respiratory adverse effects in patients with advanced COPD. Secondary objectives…
to assess the pulmonary toxicity in patients treated with cyclophosphamide compared to a control group
The primary objective is to evaluate the antitumor activity of ceritinib in patients with ALK-positive NSCLC metastatic to the brain and/or toleptomeninges based on whole body overall response rate (ORR), defined as the proportion of patients with a…
The objective of the trial is to assess the efficacy and safety of nintedanib in the treatment ofSSc with ILD at a dose of 150 mg bid compared to placebo.
Primary Objective:* To assess the effect of BGF MDI relative to GFF MDI and BFF MDI on the rate of moderate or severe chronic obstructive pulmonary disease (COPD) exacerbationsSecondary Objectives:* To assess the effect of BGF MDI relative to GFF…
The purpose of the trial is to evaluate the efficacy and safety of two different doses of QVM149 (QVM149 150/50/80 *g and QVM149 150/50/160 *g via Concept1) over two respective QMF149 doses (QMF149 150/160 *g and QMF149 150/320 *g via Concept1 in…
The primary objectives are to determine the inhibitory effect of intravenously administered C1-inhibitor as well as the influence of depletion of the human microbiota on allergic lung inflammation induced by house dust mite (HDM) plus…
The primary objectives are twofold: 1) to compare the effect of 12 weeks of multidisciplinary pulmonary rehabilitation in a high-altitude centre with comparable rehabilitation in a sea level centre on asthma-specific quality of life (assessed with…
The objective of this study is to identify genetic variations associated with clinical response and toxicity in non-small cell lung cancer patients (NSCLC) undergoing chemoradiation or chemotherapy with platinum agents (carboplatin, cisplatin). The…
Primary objective: To study physical activity of COPD patients before, during, and after pulmonary rehabilitation. To evaluate whether and to what extent our designed physical activity coaching system can support the maintainance of physical…
To better understand the progression of early CF lung disease we aim to study lipid profiles and PMN dysfunction in relation to the severity of early lung disease in infants with CF, using BALF samples and peripheral blood. To optimally study these…
The main purpose of this study is to investigate how molgramostim improves the flow of oxygen from the lungs to the blood in patients with aPAP. The effect on lung function as a whole will also be studied, along with any improvement in the patients…
To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer.
To determine the tacrolimus bioavailability after tacrolimus administration via a rectiole.
To estimate the incidence of S. aureus and P. aeruginosa ICU pneumonia, especially VAP, and to assess its association with patient-related and contextual factors, e.g. colonization status, serum antibody levels against S. aureus alpha toxin [AT],…
Optimizing (breathing) techniques for radiotherapy of esophageal and lung carcinomas; a pilot study.
Primary objective: To determine the optimal breathing technique to minimize the dose to the heart of radiotherapy for esophageal and lung cancer using current photon techniques, without compromising the dose to the lungs. Secondary Objectives: 1. To…
The main objective of the trial will be to assess safety and tolerability of combined treatmentwith nintedanib and pirfenidone.A secondary objective is to assess the exposure based on PK trough concentration values tonintedanib either given alone or…
The purpose of this study is to determine whether the efficacy and safetyof QVA149 (110/50 *g o.d.) and triple treatment with tiotropium (18 *go.d.) + salmeterol/fluticasone propionate FDC (50/500 *g b.i.d.) arecomparable in patients with moderate…
To identify and define characteristics of healthy lymph nodes and lymph nodes involved in different pulmonal diseases (lungcancer and sarcoidosis)
The primary objective of the study is as follows:· To compare the rate of asthma exacerbations between patients with low baseline periostin levels (< 50 ng/mL) and patients with high baseline periostin levels (* 50 ng/mL), as measured by…