33 results
To determine whether administration of exogenous surfactant using a minimally-invasive technique improves outcome in preterm infants 25-28 weeks gestation treated with continuous positive airway pressure (CPAP).
Part I Preclinical study using the VIRTUAL preclinical prototype Primary objective:- To validate the reliability and applicability of regular use of the VIRTUAL (pre)clinical prototype in a bed-side setting (desktop) preconceptional and across…
The main objective of this study is to analyse the effect of preeclampsia on levels of memory T cell subsets in peripheral blood.
To investigate whether bright light therapy is an effective treatment for depression during pregnancy compared with low-intensity placebo light therapy (proof-of-principle) and to investigate the late effects of bright light therapy versus placebo…
Primary Objective: To establish a prediction model for the probability of vaginal delivery and successful vacuum extraction at the second stage of labor, using the angle of progression by transperineal ultrasound. Secondary Objective(s): To evaluate…
The purpose of the sub-study is to do research into markers which will hopefully assist to diagnose the condition Peripartum Cardiomyopathy as early as possible. The blood donated for research will also assist in the assessment of women having a…
Th**is study will compare sequential mifepristone and misoprostol (*M&M*) treatment versus misoprostol treatment alone, which is currently the standard medical treatment in the Netherlands.
Primarily, to study the relation between neonatal cerebral oxygen saturation and extraction and intelligence at 4 years of age in infants born following intrauterine growth restriction. The second aim is to study the relation between neonatal…
The objective of this study is to compare the direct effect of repetitive tactile stimulation versus standard stimulation on the respiratory effort of preterm infants during stabilisation at birth. The most ideal comparison would be to compare…
To determine the vaginal microbiota composition during preeclampsia
The primary objective is to assess feasibility of a food supplement (multispecies probiotic) placebo-controlled, randomised controlled, double blind intervention in pregnant women in their late second/third trimester of pregnancy, to reduce symptoms…
Primary objective: to determine the incidence and location of thrombi in the umbilical venous catheter route during and after umbilical catheterization and in the same route in infants without umbilical catheters. Secondary objectives:A. to…
The main objective of this study is to analyse the effect of fetal sex on levels of T and macrophage cell subsets in decidual tissue. Secondary objectives will be to analyse differences in the effect of maternal blood stimulation by fetal leukocytes…
The primary endpoint will be descriptive histology on placental bed biopsies and placenta in healthy pregnant women or women with preeclampsia and/or IUGR in need of caesarean section. In particular, the study will aim to find the degree of…
To evaluate the efficacy of low molecular weight heparin (LMWH) in women with inherited thrombophilia and recurrent miscarriage on live birth.
The main objective of the study is to construct reference curves for fetal bladder diameters and volume in the second and third trimester of pregnancy. Moreover we will investigate the variation in the dimensions of renal pelvis in relation to the…
The objective was to assess the effectiveness of low-dose aspirin in the prevention of recurrent preterm birth.
The aim of the DONOR study is to define whether OD pregnancies, specifically those in which the fetus has a more distant immunogenetic relationship to the mother, are associated with more abnormal placentation and abnormal vasculogenesis, and…
This study will assess safety and feasibility of bone marrow-derived allogeneic MSCs, as administered by the nasal route, in neonates who suffered from PAIS. The ultimate goals of the present study is therefore to develop a therapy using adult human…
Primary objective: To evaluate the effect of treatment with oral hypoglycemic agents (OHA) on the incidence of large-for-gestational-age (LGA) infants in women with GDM requiring medication, compared to insulin (INS) treatment.Secondary objectives:…