42 results
We hypothesize that formerly pre-eclamptic women have persistently increased angiotensin II sensitivity, sodium sensitivity, insulin resistance and sympathetic nerve activity together initially leading to susceptibility for early renal disease and…
We would like to research wether there is a difference in time of mobilization between women getting iv PCA with Morphine (PCA)as opposed to women getting continuous epidural analgesia (CEA)with bupivacaine and sufentanil.We expect that the PCA will…
Cross-sectional study: To detect the normal range of amplitudes and segment intervals of the fECG. Case-cohort study: To compare the fECG between healthy fetuses and fetuses with various forms of severe CHD. To determine the diagnostic value of fECG…
The aim of this study is to determine whether children between 5-17 years born to women with an autoimmune disorder and prednisone use during pregnancy have chronically elevated cortisol levels compared to children born to women with an autoimmune…
Primary Objective: - Antibodies to the hepatitis B surface antigen (anti-HBs) levels 30 days after the last hepatitis B vaccine dose (11 months) in children from IBD mothers treated with anti-TNF compared to children from IBD mothers not treated…
Effect of folic acid supplementation in pregnancy on preeclampsia - Folic Acid Clinical
Trial (FACT)
Primary ObjectiveThe overall aim is to evaluate a new preeclampsia (PE) prevention strategy: 4.0mg (1.0mg x 4) of folic acid supplementation vs. placebo from early (80/7 to 166/7 weeks of gestation) pregnancy until delivery.Secondary ObjectivesTo…
To establish benchmark values in healthy control fetuses, to compare these with our cohort of fetuses with severe CHD.
The primary objective of this study is to compare the level of stress and comfort of preterm infants when sedation is given during the MIST procedure compared to no sedation.
We seek to elucidate the perinatal exposures to DEHP and BPA with the intention of providing evidence for policy makers and manufacturers. It is our hope that less toxic products will be used in health care and in the general population in the…
The proposed study has 2 main aims: 1) Understanding the complex interplay of determinants of parenting and examining how specific parenting styles explain associations between parent characteristics (such as personality or mental and physical (ill…
Primary objectives: -To evaluate the PK profile of OBE001 when administered orally to pregnant women.Secondary objectives: -To evaluate the maternal safety and tolerability of OBE001 when administered orally to pregnant women.-To evaluate the acute…
The aim of the study is to gain more insight in the course of intestinal oxygenation, urinary I-FABP concentration, and plasma Citrulline levels (as markers for intestinal damage and recovery) after NEC in relation to time to full enteral feeding…
The primary objectives of this study are to assess whether there is transfer of CZP into breastmilk of lactating mothers who are receiving an established dosing regimen of CZP by evaluatingthe concentration of CZP in mature breast milk, and to…
The primary objective is to compare metformin versus no intervention for incidence of GDM in women with a high risk for GDM. The main secondary objective is pregnancy outcome with Metformin, neonatal outcomes and neonatal complications.
Primary objectives:To determine the difference in effect of prophylactic daily LMWH injections with standard high risk antenatal care compared to standard high risk antenatal care only for the prevention of preeclampsia and IUGR and to assess the…
To assess if the *BasIQ* makes a standardized incision of 4 cm.
In this study the test characteristics of the early structural ultrasound examination (SUE) (at 13-14 weeks) will be evaluated and compared the those of the standard SUE/AUE at 20 weeks. Also, the amount of (in-)conclusive examinations and the…
The primary objective is to determine if there is an association between the presence of vertebral and/or rib anomalies and congenital malformations, aneuploidy or adverse fetal outcome, in order to assess whether detailed evaluation of the…
Now that the ProTwin study has shown an important benefit of pessary use in woman with a short cervix in twin pregnancy, long term follow-up is needed to show that there is no potential harm in using a pessary for preterm delivery prevention. We…
In this study we will assess the optimal analytical conditions for routine laboratory GDM screening in the Netherlands, possible discrepancies in clinical outcome due to (pre)analytical variation and the applicability of POCT testing in GDM…