79 results
To evaluate the effect of KW-3902IV in addition to IV loop diuretic therapy on heart failure signs and symptoms, persistent renal dysfunction, morbidity and mortality, and safety in subjects hospitalized with acute heart failure syndrome, volume…
In this study we will study the incidence of QTc-interval prolongation when combinations of 2 or more QTc-prolonging drugs are prescribed. Also we will investigate if QTc-prolongation is more frequent in patients with higher drug plasma…
The primary hypothesis of our study is that volumetric monitoring will allow for more effective and targeted fluid administration compared to pressure (PAC) monitoring, thereby allowing the attending physician to better optimize fluid infusion…
There are two phases in this trial with 2 objectives:In phase I of the trial it will be assessed which dose of rivaroxaban is the most safe and effective (most optimal benefit:risk profile). In phase II this dose will be further investigated to…
The primary objective of this study is to establish the effects of a single bolus EPO administered just before a primary PCI for a first acute myocardial infarction, on left ventricular ejection fraction after 6 weeks, measured with planar…
The primary objective of this study is to demonstrate that the efficacy of cangrelor (combined with usual care) is superior to that of usual care, in subjects requiring percutaneous coronary intervention (PCI) as measured by a composite of all-cause…
To study the feasiblity of cardiac MRI at 3T and the potential benefits of the intravascular contrast agent gadofosveset for studying and quantifiaction of heart function and -perfusion.
To investigate whether COX-2 inhibition enhances platelet aggregation by suppression of prostacyclin formation without suppressing thromboxane formation
Aim of this study is to identify how pregnancy complications can be predicted from the interplay between psychological, social and somatic risk factors. We hypothesize that the personality trait neuroticism predisposes to complications of pregnancy…
The purpose of this study is to do research what the effect of the BMI and fat percentage is on the speed of cooling.
To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…
The primary objective of this study is to evaluate safety and efficacy of the BIOTRONIK PRO-Kinetic coronary CoCr-stent in patients with single de novo lesions of native coronary arteries.
Does melatonin by improving sleep parameters improve quality of life of hemodialysis patients?
Secondary HPT is common in people with CKD. Patients with secondary HPT often have high PTH levels and may develop large parathyroid glands in the neck. Patients with secondary HPT may have bone disease (osteodystrophy). This bone disease may cause…
The objective of the current study proposal is to gain insight in the effect of pulmonary vein isolation on the electrophysiological properties nearby the ablation lines on the posterior sight of the left atrium and further away, especially in the…
To find the predictors of ventricular arrhythmias in patients receiving an ICD
Primary:Comparing EPO induced proliferation, G2/G0 ratio, and apoptosis of UT7-EPO cells between anemic and non-anemic CHF patients. Secondary:1. Comparing the levels of several circulating inhibitory factors (TNF-alpha, TGF-Beta, Ac-SDKP, INF-gamma…
Monitoring the haemodynamic status during lung recruitment.
The primary objective is identification of a set of genes as candidate monocyte markers for acute coronary complications and subsequent identification of a prognosis classifier to discriminate vulnerable, stable, and control subjects, based on the…
To determine the mean systemic filling pressure, the arm-occlusion pressure, the cerebral zero flow pressure and their response to changes in volume status and vasoactive medication. To evaluate and confirm the value of mean systemic filling…