1237 results
Primary Objectives-To evaluate if mitochondrial dysfunction can be induced in healthy, middle aged subjects, through the use of simvastatin, and whether it can be reversed by oral ubiquinol supplementation. -To validate the techniques NIRS, PpIX-…
The main objective of this study is to understand how the brain selects information using attention: what determines which information is selected and how does this selection occur? An important component of this project will be aimed at researching…
Purpose of the study is to investigate neurocognitive and behavioral development in children of morthers with epilepsy, primary school age, and who were exposed to anti-epileptic drugs in utero. Primary research questions are: 1. what is the nature…
This study primarily aims to explore changes in physical activity pattern and energy expenditure in head and neck cancer patients, during and after treatment with surgery with or without (chemo)radiation. The secondary aim of this study is to gain…
This study aims to assess the acceptability and usability of the ECH system from the perspective of patients, their informal carers and their clinicians in a routine outpatient setting for patients with recurrent depressive or bipolar disorder. A…
Objective 1To describe the course and underlying mechanisms of dysphagia in children with congenital myopathy (from 6 months to 12 years)Objective 2To formulate recommendations for early detection, diagnostic assessment , treatment and advices for…
The aim of this study is to explore the elementary components in shared goal-setting in patients with no-option CLI. The transcending benefits of this study will apply to doctor-patient communication in general. The primary objective of the study is…
We propose a prospective cohort study to identify the incidence of responsiveness as a surrogate of anesthesia awareness following laryngoscopy in standard clinical practice.
Investigate the phenotype, function and regulation of TRM in healthy human lung tissue, lung tumors and peripheral blood to improve the understanding of respiratory diseases and adoptive T-cell therapy for lung cancer.
High-field (7T) MRI and genetic biomarkers for neurocognitive impairment in type 2 diabetes melltius
The primary objectives: 1. To tailor and apply high-field multi-parametric and functional MRI techniques to identify cerebral biomarkers in DM2 and MetS patients compared to control subjects.2. To examine a specific set of genetic hypotheses in DM2…
This study has two objectives: (1) To determine the influence of joint angular velocity on torque production in the shoulder joint during functional movements in young adults, healthy elderly and elderly with subacromial pain syndrome. (2) To…
* To examine the effects and interactions of individual and environmental factors on the onset and course of mental health problems in adolescents and young adults.* To examine the effects and interactions of individual and environmental factors on…
We expect to gain insight in the difficulties in comunication in medical settings. This insight will help to improve the training of doctors and other caregivers. We also think that it can improve interventions directed to prevent and solve problems…
The primary objective of this study is to identify in what manner micro- and macro hemodynamic parameters responds to critical illness and therapy, and to determine how this interaction is related to different states of organ dysfunction (heart,…
This study is part of a prospective cohort study in the University Medical Center Groningen aimed at the determination of prognostic factors for outcome of children with TBI. The study is a pilot study to determine the value of fNIRs for detection…
1. To evaluate and optimize a protocol for quantifying brown adipose tissue with MRI and to assess BAT volume per patient. 2. To assess the reproducibility of MRI measurments by determining, inter-scan, intra-observer and inter-observer variability…
The aim of our studies is to explain weight gain in individuals based on their geneticpredisposition, and their physiological and behavioral responses to the current obesogenicenvironment and to define personality subtypes, which specify the…
The purpose of this study is to determine whether the first immunization causes cardiorespiratory events in premature born children that have already been discharged from the hospital.
The primary objective of this study is to assess the association between pre-dialysis comprehensive geriatric assessment and early death or withdrawal from dialysis (<6 months) in patients aged over 65 years
Our aim is to make ROM suitable for patients of Moroccan or Turkish origin. In order to achieve this, necessary steps need to be taken: (1) translate and cross cultural adapt ROM questionnaires; (2) validate the translated questionnaires; and (3)…