229 results
Evaluate whether CT lung densitometry and PWV associate with plasma DES concentrations. In addition, we want to determine whether certain other laboratory determinations in the blood and condensed exhalation vapor correlate with plasma DES.
Objective: The primary objective of this study is to evaluate the pharmacokinetics of midazolam in elderly patients (>70 years) admitted to the ICU.
Victims of IPV, living in an unsafe and unhealthy situation, are faced with a broad range of physical and emotional symptoms. Standard and easy-accessible care to facilitate change into a safer situation is lacking. The project aims to launch an…
Taken together, social performance monitoring processes and empathic abilities are key ingredients for efficient social behavior. Possible disturbances in these processes may severely inhibit or even impair social interactions with possible long-…
To investigate if a personalized dietary advice is more effective in increasing dietary fiber intake in the Dutch population than the general advice that is currently provided by the Netherlands Nutrition center and the Dutch Digestive Foundation (…
In this study we want to investigate how a perturbation-based treadmill training with cognitive dual-task improves daily life gait stability in older adults compared to conventional treadmill training with cognitive dual-task.The results of this…
The collection of data of the orofacial motor skills with the OMOK in healthy children between 2 and 8 years.
To determine the content validity and clinical utility of the Dutch sPCI according to nurses with expertise in stroke care and stroke patients, respectively.
Smell and taste function change during chemotherapy consequently affecting 1) dietary intake 2) eating behavior 3) anthropometry 4) quality of life
The primary goal of this study is to gain a better understanding of how dementia affects the multimodal expression of emotions in face, gestures, verbal and non-verbal expressions when discussing emotional laden autobiographical memories. Therefore…
1] To explore the course of performance-based physical functional recovery at ICU admission, hospital discharge, three months post-hospital discharge and at six months post-hospital discharge of ICU survivors who have been * 48 at mechanical…
To assess the accuracy of a Bayesian-based, patient-individualized, pharmacodynamic advisory system to optimize propofol effect-compartment-controlled administration using the qCON index as a controlled variable versus qCON-guided effect-compartment…
In this study we aim to compare postprandial chylomicron/lipid responses in Alzheimer patients and cognitively healthy people and to determine to what extend produced chylomicrons are loaded with Abeta.
Relapse after an intensive rehabilitation program is a problem, the additional intervention which is developed aimed to prevent this. The intervention is innovative and no alternatives are known in the literature.The following practical questions…
Primary Objective* To evaluate the efficacy of VX-561Secondary Objectives* To evaluate the pharmacodynamic (PD) effect of VX-561* To evaluate the pharmacokinetics (PK) of VX-561, IVA, and relevant metabolites* To evaluate the safety and tolerability…
- To investigate the long-term outcome of the intervention strategy for FGR (induction of labour) that is worldwide applied after the original DIGITAT study, in relation to induction of labour versus expectant management.- To investigate…
The study will be performed in 2 cohorts, Cohort 1 and Cohort 2. In Cohort 1, it will be investigated what the effect is of itraconazole on how quickly and to what extent APX001 is absorbed and excreted by the body (this is called pharmacokinetics…
Primary ObjectiveTo determine the plasma and cerebrospinal fluid (CSF) pharmacokinetic (PK) profile of multiple oral doses of CAD-1883 in healthy subjects.Secondary ObjectiveTo evaluate the safety and tolerability of multiple oral doses of CAD-1883…
To assess whether tianeptine is able to antagonize opioid-induced respiratory depression.
To evaluate the effect of a newly developed artificial saliva spray on the relief of a dry mouth sensation in Sjögren syndrome patients