341 results
Primary objective is to gain insight into risk acceptation of serious adverse events (<30 days) in bariatric surgery. Secondary objectives are the expected weight loss, risk acceptation of mortality, risk acceptation of serious adverse events…
In patients with neoadjuvant disease the purpose of the study is to define the safety and tolerability of the drug. In patients with metastatic disease the purpose is to determine if treatment with Nivolumab or Nivolumab and ipilimumab will lead to…
Objectives for Part A1 Monotherapy Dose EscalationPrimary Objective:* To assess safety, and tolerability at increasing dose levels of PF 04518600 in patients with selected advanced or metastatic solid tumors in order to establish the MTD.Secondary…
The main goal of the study is to assess the incidence of respiratory events using the IPI device.
A) To investigate the pharmacokinetics and determinants of MTX-PG accumulation in plasma and erythrocytes in adult CNS lymphoma and leukemia patients treated with HD-MTX;B) To investigate whether intracellular MTX levels are related to toxicity in…
Obtain normative data within similar age-range as our clubfoot patients.
Efficacy ObjectivesThe primary efficacy objective for this study is as follows:• To evaluate the efficacy of adjuvant atezolizumab treatment in patients with PD- L1*selected muscle invasive urothelial cancer, as measured by disease-free survival (…
The primary objectives of this study are:* To describe the safety and tolerability of cergutuzumab amunaleukin in combination with atezolizumab* To determine the MTD, if achieved, of cergutuzumab amunaleukin in combination with atezolizumab* To…
Primary ObjectivesPart A: RO6874281 Dose Escalation as a Single AgentThe primary objectives for this study are as follows:* To describe the safety and tolerability profile of RO6874281 as a single agent* To determine the maximum tolerated dose (MTD…
The objective of the study is to investigate if predictors of cardiac responsiveness are able to predict a renal response to fluid administration in oliguria.
To assess the efficacy and safety of 2 dose levels of NTRA-2112 on intestinal malabsorption in preterm infants as compared to placebo.The sub-study aims to determine whether NTRA-2112 in own mother's milk, donor human milk or preterm formula…
Managing victimization risks attached to societal participation by people with severe mental illness
The main objective of the study is to gain insight in the effectiveness of the Victoria modules, in terms of acknowledgement for these experiences and risk awareness. These experiences and insights can be used to take acceptable risks in…
The current study will examine the safety and pharmacokinetic profile of JWH-018.
The main objective is to evaluate the percentage of patients that do not experience progression during the first 18 weeks of treatment with Atezolizumab in patients affected by advanced solid tumors.The secondary objectives are to evaluate the…
• To evaluate the proportion of childhood cancer survivors that reach peak bone mass• To evaluate the incidence rate of fractures of CCS as compared to normal controls• To investigate patients at (treatment or diagnosis related) risk for decline of…
This study is aimed at assessing the course of the symptoms during the current treatment protocol, which aims to reduce PTSD symptoms. The study could possibly also say more about quality of life, comorbidity, and various socio-demographic data of…
This DCOG-LATER project proposal aims to characterize the overall, disease and treatment-related risks of sexual dysfunction and delays in psychosexual development in a Dutch cohort of 5-year CCS treated in the period 1960-2001 and to evaluate the…
The aim of this clinical trial is to evaluate the feasibility, efficacy and acceptability of abatacept therapy in subjects at high risk of developing RA.
The main objective of this study is to investigate whether rTMS add-on treatment will improve clinical outcomes in alcohol dependence. The secondary objective will be to answer the question through which mechanism rTMS will improve treatment…
The POINTER trial investigates whether immediate treatment with catheter drainage is superior to the current practice of postponed catheter drainage within the step-up approach in patients with infected necrotizing pancreatitis.