642 results
To determine whether increased calcium and phosphate intake (2005 group) resulted in improved Bone Mineral Content (BMC) and Bone Mineral Density (BMD) compared to the group with less calcium and phosphate intake (2004 group) at the age of 8-10…
The objective of this study is to assess whether oral exposure to beer and non-alcoholic beer elicits similar reward responses in the brain in a setting where only beer is expected. This knowledge will give fundamental insight in whether alcohol is…
Primary objective:Increase in left ventricular ejection fraction after bariatic surgerySecundary objectives:Reduction of paracardial fat after bariatic surgeryReduction of visceral abdominal fat after bariatic surgeryReduction of hepatic steosis…
Primary objective:To examine the effect of stress reduction through heart rate variability (HRV) biofeedback + psycho-education (condition 1) in pregnant women with at least moderate levels of stress, and their partners, as compared to psycho-…
The objective of the study is to determine whether exposure to the SpectraMax light therapy device, emitting light in a combined spectra of blue/green light (460 * 570 nm) with an intensity of approximately 1300 Lux, will be more effective in…
Primary:The primary objective of Study 218MS305 is to determine whether prolonged-release fampridine (10 mg BID) has a clinically meaningful effect on patient-reported walking ability over a 24-week study period.Secondary:The secondary objectives…
Purpose of the study is to investigate neurocognitive and behavioral development in children of morthers with epilepsy, primary school age, and who were exposed to anti-epileptic drugs in utero. Primary research questions are: 1. what is the nature…
The effects of intravenous TRH administration on brown adipose tissue activity in healthy, lean men.
To investigate whether BAT tissue can be activated by intravenous administration of TRH. Secondary objectives are to determine whether intravenous TRH increases the degree of cardiovascular sympathetic stimulation and the response of skin…
The goal of this study (mono-center study) is to study the effect of renal denervation with the EnligHTN Renal Denervation System on sympathetic nerve activity.
The goal of this study is obtaining knowledge about the effectiveness of a training that aims to decrease victimisation of dual diagnosis patients.The primairy research question is:- What is the effect of the SOS-training on the frequency of…
The main objective is to determine the difference in serum POP concentrations in two groups of Dutch men consuming eel, namely the men consuming eel from polluted areas ('high* exposed) and those men consuming eel from clean areas (*low*…
The main objective of this study is to understand how the brain selects information using attention: what determines which information is selected and how does this selection occur? An important component of this project will be aimed at researching…
1) To investigate the effect of atomoxetine on resting-state fMRI measures of network functional connectivity.2) To assess the effect of atomoxetine on several task performance variables, that are hypothesized to reflect tonic LC-NE activity.3) To…
The main objective of the study is to investigate the development of and relationship between visual perception and social behavior in infants and toddlers. Secondly, the the stability of measurements in infants and toddlers will be investigated.
Recent studies demonstrate long-term durability of virologic response with pegylated alpha-interferon-based therapies. Comparable information is not yet available for Lambda or for regimens combining lambda interferons, RBV, and DAAs. In this…
The primary objective for part I of the study is the investigation of the pharmacokinetics. Although there is substantial clinical experience with all components of HTX-011, the formulation itself and the route of administration is new, which…
Primary Objectives-To evaluate if mitochondrial dysfunction can be induced in healthy, middle aged subjects, through the use of simvastatin, and whether it can be reversed by oral ubiquinol supplementation. -To validate the techniques NIRS, PpIX-…
Primary Objectives:• Part 1: To evaluate the safety and tolerability of ruxolitinib in combination with pemetrexed/cisplatin and select a dose for further evaluation• Part 2: To evaluate and compare the overall survival of subjects with nonsquamous…
The current study aims to evaluate the effectiveness of an individual online self-management program called *Partner in Balans* in increasing feelings of self-confidence and preventing depressive complaints in family caregivers of patients with (…
To investigate how quickly and to what extent diclofenac is absorbed and eliminated from the body (this is called pharmacokinetics) when it is administrated by using a HP 5000 transdermal patch. Furthermore, the pharmacokinetics of HP-5000…