748 results
To provide subjects who have completed participation in a Phase 2 or Phase 3 trial continued access to therapy and to evaluate the long-term safety and tolerability of leuco-methylthioninium bis(hydromethanesulfonate) given in flexible doses of up…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…
The main objective of this study is to detect potential biomarkers for the differentiation of PD and DLB and the differentiation of PD subtypes by using neuroimaging.
The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…
The NEURONED-MS cohort study aims to facilitate prospective observational research in the field of multiple sclerosis (MS). This cohort will serve as the central part of several projects that will be organized to address various issues including:1.…
To study neuronal and ophthalmological characteristics of a newly detected clinical entity called slow vision which hampers visual perception and attention of the affected patients.
Objectives- To study presence of (Cortical) Spreading Depression ((C)SD), using direct current (DC) EEG changes in migraine patients during different phases of the migraine attack;- Is there a change in DC-EEG recordings suggestive of (C)SD,…
To establish benchmark values in healthy control fetuses, to compare these with our cohort of fetuses with severe CHD.
In the literature the effectiveness of the anterior cervical discectomy is measured using subjective validated questionnaires.It would be an important improvement if it is possible to detect the inflammatory process of the dorsal root ganglion with…
The aim of the present study is to investigate the reproducibility of upper extremity strength measurements in children with CP. The following strength measurement instruments will be studied: Hand Held Dynamometry (HHD), pinch- and grip strength…
The main aims of our study are 1) to make a clinical inventory of MD cases, 2) to identify (modifier) disease genes underlying MD and 3) to link the clinical data with the genetic data in a data-base.
Primary Objective: To evaluate intracranial venous haemodynamics in single suture craniosynostosis, and to determine the effect of surgery.Secondary Objective: Provide insight in the relationship between venous haemodynamics and intracranial…
(1) To determine the frequency of antibody-mediated encephalopathy in children with seizure-related or (sub)acute onset neuropsychiatric disorders. (2) To identify the target auto-antigens of selected seizure-related and (sub)acute onset…
The primary aim of this study is to evaluate the feasibility, clinical effectiveness and cost effectiveness of a caregiver mediated exercises programme combined with e-health services (CARE4STROKE+) to improve self-reported health status and reduce…
Molecular genetic testing for SEPT9 mutations is clinically available, but is not of much added value, at least in the Netherlands because of the low prevalence of SEPT9 mutations observed in Dutch HNA patients. Objective 1: To identify with WES de…
To assess in moderate preterm infants:1) The prevalence and characteristics of brain injury; 2) The relation between perinatal factors and brain injury;3) The validity of cUS for detection of brain injury as compared to MRI (considered the golden…
Determine the effect of rectus femoris transfer on stroke survivors walking with a stiff knee gait on functional-, activity- and participation level.
Research questions:1. Does music therapy improve the expressive and communicative skills of patients with HD due to (specific) music therapy treatment? 2. Does music therapy change problem behavior of patients with HD?
The primary objective of this study is to assess whether a liberal (6.5 mmol/l) transfusion strategy compared to a restrictive (6.0 mmol/l) transfusion strategy lowers the incidence of major adverse cardiac events (MACE). MACE is defined as a…