171 results
- Six weeks of ESM combined with personalized feedback sessions, compared with treatment as usual (TAU), leads to a stronger reduction in fatigue symptoms (primary outcome clinical effectiveness). - This intervention also leads to improvements in…
The main objective is to study the effect of a nutritional intervention on white matter integrity at the corrected age of three months in infants born at a gestational age <30+0 weeks. Secondary objectives of the study are to determine the…
The experimental treatment (game-supported TPM training) will contribute to a more effective generalisation of compensatory strategies to untrained tasks as compared to the active control group (CogniPlus training).
The primary objective of this study is to evaluate the effect of surgical correction of pes equinovarus deformity compared to conservative treatment on personalized goal attainment. In addition, we will evaluate the effect of surgical correction of…
To investigate the effect of a three-week treatment with cannabidiol (CBD) on anxiety in patients with a primary brain tumor that have no active oncological treatment. Depression, fatigue and general quality of life are secondary outcome measures.…
Primary objectives: 1. Assess the feasibility of FMT in PD patients. 2. Assess the safety of FMT in PD patients. Secondary objectives: 1. Explore whether FMT leads to alterations in motor complications (fluctuations or dyskinesias) and…
This study will investigate the potential value of CFX treatment, by prospective monitoring of functioning in patients that undergo this treatment. Likewise, aspects of the treatment that are important for patient experience will be systematically…
To assess the association between secondary brain injury in intracranial haemorrhage and the involved inflammatory response. We want to correlate perihematomal inflammation, serum inflammation markers, increased blood-brain-barrier leakage and…
To assess cognitive impairment in participants with highly-active RMS, having participated in the CLARIFY MS trial, at 4 years afterinitial dose of cladribine tabletsTo assess health related quality of life (HRQoL) in participants with highly-…
The primary objective is to measure the dose of cerebral ischemia, as a measure of cerebral hypoperfusion, before, during and after aortic arch surgery. Secondary objectives include parameters that influence the occurrence of cerebral ischemia (…
The primary objective is to develop algorithms that define digital biomarkers for disease progression in Progressive Supranuclear Palsy patients. The biomarkers, when developed systematically, can eventually serve as primary or secondary clinical…
The primary aim of this pilot study is to evaluate whether adding BoneMRI to the current workflow, which consists of a standard MRI scan and only on indication an X-ray or CT scan, improves the neurosurgeon satisfaction and certainty in the surgery…
To report on the long-term effect modification by age of MPH treatment on brain structure and function, and clinical outcome, as measured by MRI scans, neuropsychological assessment, actigraphy and questionnaires, and to compare these results with…
To evaluate experiences with and fidelity to the individually delivered Managing Fatigue (MF) program of community based occupational therapists and patients with FSHD or MM. Secondary aims:Participants:- To detect which strategies of the MF program…
Primary objectives: To determine and compare the diagnostic yield of two different methods (FaceReader technology and a deep learning model specifically developed for video data) to analyse facial weakness from video recordings (04:00m) with…
The aim of this PMCF study is to confirm the clinical safety and performance aspects of intracranial catheter placements forthe medical indications, hydrocephalus of any origin or ICP elevation. The study design requires determination of…
The primary objective of this study is to investigate the difference in brain activation in response to odour stimulation between patients and controls. The secondary objective is to investigate the relationship between smell ability and brain…
The primary objective of this study is to compare cholinergic innervation of the cerebral cortex of GBA-PD and non-GBA-PD patients, using [18]FEOBV PET imaging of the brain.
Part 1 Single Ascending Dose (SAD)- To evaluate the safety and tolerability of a single oral dose of prodrug, ABX-002, in healthy adult subjectsPart 2 Multiple Ascending Dose (MAD)-To evaluate the safety and tolerability of once daily oral doses of…
To assess the effect of treatment with 100 mg of FAB122 (edaravone) on disease progression in patients with ALS.