170 results
Extracellular vesicles (EVs) in plasma can be used as a biomarker for stroke diagnosis, thereby discriminating between ischemic and hemorrhagic stroke.
It is hypothesized that bCBT for severe fatigue will lead to clinical improvements in fatigue levels compared to usual care.
Our main objective is to develop and validate body fluid biomarkers that detect CAA in Alzheimer*s Disease patients during life.
Our primary objective is:i. To assess the quantity and regional distribution of [18F]DPA-714 binding as a marker of microglial activation in patients with FTD compared to controls. Our secondary objectives are: i. To compare the quantity and…
1) to study the effects of 4 weeks of HIIT compared to 4 weeks of CAE on motor and non-motor aspects of PD; 2) to investigate the association between blood biomarkers for neuroplasticity / neurodegeneration and motor and non-motor performance for…
Primary:To determine the efficacy of AG10 in the treatment of subjects with symptomatic transthyretin amyloid polyneuropathy (ATTR-PN) by evaluating the difference between the AG10 and placebo groups in Modified Neuropathy Impairment Score + 7 (mNIS…
We aim to study the effectiveness of an intervention provided by nurse practitioners who will:- Provide conversations on Advance care planning (ACP);- Coordinate care based on patients needs at advanced stage;
1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…
The main objective of the study is to evaluate the effect of BoNT-A injections on the intrinsic an reflexive contributions to ankle joint resistance for patients with spasticity. We hypothesize that, with respect to baseline, reflexive joint…
Overall the safety to perform FMT has to be assessed before potential trial powered for efficacy can be performed. In this study we aim to treat 10 patients with different forms of MS to assess if FMT is safe to perform.Primary Objective: To assess…
The purpose of this explorative study is to investigate whether treatment with lactate has any positive effect on the symptoms of GLUT1DS, especially the drug-resistant epilepsy.Primary Objective: - To assess changes in EEG during and shortly after…
Main objective: We propose a proof of concept study to apply noninvasive brain stimulation, specifically tACS, for the first time to adult CG patients with the aim to find stimulation protocols that improve their motor and language performance by…
Overall aim: To examine the association between olfactory function, motor, and non-motor symptoms in a longitudinal cohort of PD patients.Specific objective(s): 1. To determine whether the degree of hyposmia in PD is associated with disease duration…
Primary• To evaluate the effect of ravulizumab on adjudicated On-Trial Relapses in adult patients with NMOSDSecondary• To evaluate the safety of ravulizumab in adult patients with NMOSD• To evaluate the effect of ravulizumab on adjudicated…
Objectives: 1) Assess neural and cognitive biomarkers (through eye-tracking, EEG/ERP and cognitive measures) in a community sample of infants at heightened non-familial risk for ASD and in age and gender matched low-risk controls. The HR group is…
The present study examines stroke patients* language abilities as well as the recruitment of additional brain areas in language use over time to compensate for stroke-induced language deficits.
Primary objective:Does the use of the application support a positive lifestyle development?Secondary objectives:Does the use of the application support an increase in physical activity levels?Does the use of the application has a positive influence…
Translation of [18F]-MC22518 to the clinic to measure P-gp function in healthy volunteers.
To explore the effect of single versus repeated preconditioning on circulating blood factors (i.e. metabolomics analysis) as a likely mechanism in patients with cSVD. Secondly, we explore whether the effects of single versus repeated preconditioning…
The first objective is to validate novel digital biomarkers for disease progression in de novo Parkinson*s disease patients. The biomarkers can eventually serve as a primary clinical endpoint in additional future clinical studies. As part of this…