147 results
Thermoregulation in patients with spinal cord injury and cold sensations, an explorative pilot-study
To investigate whether SCI patients with regular complaints of cold sensations in daily life have more impaired thermoregulatory responses to changes in environmental temperature compared to SCI patients who do not have these cold sensations in…
Primary objective: To classify the effect of the pharmacogenetic profile of CYP2C19 and CYP2D6 in HD gene expansion carriers on negative medication effects of HD-related medication with an actionable drug-gene interaction in the…
Both interventions (GRAIL training & endurance and strength training (control intervention)) will result in an increase in gait speed, functional walking ability and social participation. However, the GRAIL training will result in larger…
Personalized orthotic care is expected to be more effective and cost-effective compared to usual orthotic care.
1) Establish a comprehensive clinical and antibody profile of autoimmune synaptic encephalitis in dementia syndromes. 2) To assess outcome and provide diagnostic guidelines who to test and in whom testing will be unnecessary, and elucidate…
Primary Objectives1. To assess pruritus and rash after administration of Neublastin or placebo in healthy subjects and migraine patients (Parts A and B)2. To assess headache and other migraine-associated symptoms after administration of Neublastin…
The objective of the study is to set up and validate a digital neurotraumatology quality registry, to identify the most effective clinical care and to provide high quality evidence in support of treatment recommendations and guidelines.
BEWARE 2.0: body awareness training for wearing-off related distress in Parkinson's disease patients
Do patients that receive the BEWARE training have a higher score on the Chronic Illness Acceptance Questionnaire at the end of treatment (and at 3 month follow-up) compared to the treatment as usual (physical therapy only)?
The primary objective of this study is to evaluate the effects of intrathecal (IT) administration of SHP611 (also known as TAK-611) on the time to loss of locomotion, as indicated by category 5 or higher in the Gross Motor Function Classification in…
The objective of this study is to test the feasibility, functionality and comfort of the AFO as an aid to regain the active RoM of the ankle joint in UMND patients with equinus foot. Results of the study will be used to further optimize the AFO…
The objectives of this study are to:• Assess safety and tolerability of imlifidase in combination with standard IVIg treatment in GBS subjects• Evaluate pharmacokinetics of imlifidase• Evaluate pharmacodynamic profile of imlifidase• Evaluate…
Main objectives:To evaluate the safety and tolerability of Lu AF28996 after up-titration of oral dose(s) in patients with Parkinson's Disease (PD)To investigate the pharmacokinetic properties of Lu AF28996 after up-titration of oral dose(s) in…
Primary Objectives: 1. To evaluate the safety and tolerability of UB-312. 2. To evaluate the immunogenicity of UB-312 as determined by anti-alpha-synuclein (anti-aSyn) antibodies in blood and cerebrospinal fluid (CSF).
Primary objective: To classify the effect of the pharmacogenetic profile of CYP2C19 and CYP2D6 in HD gene carriers, compared to more classic medication prescribing parameters (such as age and comorbidities) on negative medication effects of HD-…
The primary purpose of this study is to improve detection rate of (small) structural brain lesions by using ultra high field MRI in patients with focal drug-resistant epilepsy, and to use this information to improve seizure outcome one year after…
Primary Objective: Our objective is to validate the safety, measured by radiological disease activity, of personalized extended interval dosing of natalizumab to >=6 weeks (with an aim natalizumab trough concentration of 5 µg/ml) in a large…
1. To quantify brain iron accumulation in patient with HD using quantitative susceptibility mapping (QSM) at ultrahigh field (7T) as compared to healthy controls (case-control design).2. To link QSM results with specific and well-known clinical CSF…
The goals of the Urimon study is to test the hypothesis that microRNA expression profiles in periodic urine- and blood samples from individuals can be used for the sensitive detection of the onset of disease.
Objective: The primary objective is to improve defining clinical phenotypes of PHN patients using the following diagnostics; questionnaires, QST, blood and cerebrospinal fluid (CSF) assessment and skin nerve fiber density measurements. The secondary…
Primary: to determine the long-term safety and tolerability of SAR442168 in RMS participants. Secondary: to evaluate efficacy of SAR442168 on disease activity, assessed by clinical and imaging methods.