174 results
Primary objective: To evaluate the efficacy of IVIg treatment (4 courses of treatment, 3 weeks apart) compared to placebo on pain alleviation. Secondary objectives: 1. Pain intensity, pain qualities, and other SFN related complaints, daily and…
To study cognitive and behavioral outcome and resting-state dynamics in children with a history of perinatal asphyxia before and after the introduction of hyothermia and to compare these data with a group of controls.
The objectives are to evaluate the long-term safety and tolerability profile of aducanumab in subjects with early AD, and to evaluate the long-term efficacy of aducanumab treatment as measured by clinical, radiological and additional assessments…
To examine whether providing feedback to patients immediately after scoring in a non-valid range on a SVT would have an impact on subsequent symptom validity and neuropsychological test performance. Furthermore, we examine treatment-outcome as a…
1. To investigate the size of the HCHWA-D population by identifying all (possible) mutation carriers and their relatives. 2. Study the genealogy and natural disease history of these carriers.3. Get insight in possible genetic, environmental and…
Primary objective:1) Does individually tailored robotic gait training with the LOPES II result in more reduction of mechanical work during walking and more improvement of gait symmetry than conventional gait training (of similar frequency and…
To determine whether AFOs optimized for stiffness in patients with calf muscle weakness are superior to standard AFOs in reducing walking effort, as measured by energy cost of walking (ECW, in Jkg-1m-1), and 2) to build a model to predict required…
Primary objective:To assess the efficacy of PXT3003 compared to Placebo on the disability measured by the ONLS score in CMT1A patients treated for 15 months.Secondary objectives:- To assess the efficacy of PXT3003 compared to Placebo on clinical and…
The primary objective is to study the relationship between DAI lesions on conventional MRI, clinical parameters and prognosis. As secondary objective is the additive value of more advanced MR Imaging in which white matter tracts are analysed (as…
Primary Objective: To assess the difference in prevalence of pituitary dysfunction between patients with and patients without fatigue after ischemic stroke. Secondary Objectives: 1. To assess the time course of pituitary dysfunction after ischemic…
To explore whether patients with SCN9A-associated SFN have an abnormal brain activation pattern on resting state fMRI and altered structural connectivity on DTI versus age- and gender-matched healthy controls. With this knowledge, objective pain…
POTENTIAL will be the first phase II RCT to assess the effects of combined cerebellar tDCS and VR-PFT in terms of outcomes at the level of body functions, activities and participation, as well as brain reorganization post stroke. Ultimately,…
Objectives: 1. The first objective is to determine the nature and spatial distribution of sonographic abnormalities in CIAP and in CIDP, MIDN and MMN. 2. On the basis of the findings in objective 1, we will define a standardized HRUS research…
This study will be conducted as a prospective, observational study of patients with relapsing forms of MS initiating treatment with Plegridy in routine clinical practice and patients who participated in Study 105MS302 or Study 105MS303. Enrolled…
Primary objective of this study: To establish glycocalyx properties of temporal lobe epilepsy (TLE) patients. Secondary objectives of this study:- To establish differences in glycocalyx properties of glycocalyx between TLE patients and controls.- To…
The primary objective of this research programme is to develop a new functional architecture of the visual brain based on two concepts: the methodology to establish necessity and the theoretical framework of cortical networks. In addition, this…
Primary objective of this study is to improve identification of epileptic HFOs in EEG and MEG, by comparing them to HFOs in corticography. Secondary objectives are to study the predictive value of non-invasively recorded HFOs for disease activity…
The primary objective of TRIHEP 3 is to evaluate the efficacy of triheptanoin in (i) increasing the short term energy response in the metabolic profile of the brain of early affected HD patients, as captured by 31P-MRS, and (ii) slowing atrophy in…
The overall objective of this study is to develop patient friendly and unobtrusive techniques to characterize motor function. In this context we will use video cameras combined with depth sensors (RGB-D sensors, such as Microsoft KinectTM) and…
Objective 1: To prospectively evaluate the utility of C-FLOW monitor to examine status of regional CBF and reperfusion in patients presenting with acute anterior circulation ischemic stroke syndrome. Objective 2: To assess the feasibility,…