273 results
The main objective of the study is to determine the PK and PD of IVIg during maintenance treatment in patients with CIDP. These data will be used to conduct a NONMEM analysis in relation to the dosage, frequency and batch of IVIg used. The secondary…
- To identify the causes of inflammation of adipose tissue, liver and blood leukocytes by focusing on the contribution of the gut microbiota taking into account dietary habits and genetic background.- To assess the influence of inflammation of…
1. To assess neuroimaging hallmarks of RVCL disease stages;2. To evaluate cerebrovascular reactivity as a biomarker of endothelial (dys)function in RVCL patients, in migraine patients and healthy controls;3. To identify shared pathophysiological…
The main objective of this pilot study of n-of-one trials is to determine the effect of add-on treatment with ephedrine for all participants enrolled in this small series of n-of-one trials. Secondary objectives include determining the effect in…
The main, primary objective of this study is identification of the molecular mechanisms that regulate structure and function of red blood cells in patients with neurodegeneration accompanied by the presence of abnormal red blood cells (…
1. Is there a decreased total peripheral resistance in supine patients with VVS after challenging them with nitroglycerine? 2. Is there a decreased total peripheral resistance in migraine after infusion of nitroglycerine? 3. What is the relation…
Primary ObjectiveTo evaluate the effect of a tailored behavioral change intervention comprising CBT and physical activity on participation (as measured by the DM1-Activ scale) for severely fatigued patients with myotonic dystrophy type 1 compared to…
To explore how HD mutation carriers experience suicidal ideation, plans, or previous suicide attempts (from now on jointly referred to as suicidality), how they cope with suicidality, and which ideas and wishes HD mutation carries have on how…
Identify the effect of tDCS parameters on motor learning in healthy individuals by measuring effects on visuomotor adaptation rate and retention, and study the influence of a common BDNF mutation.
Primary Objective:The primary objective is to compare the pain free rates at 15 minutes following the use of GammaCore® with that of a sham device, for acute treatment of cluster headache attacks.Secondary Objectives:The secondary objectives will…
The specific aims for this study are to identify whether a structured exercise programme:a. is feasible for people with HD, in terms of adherence, process and safetyb. improves physical fitness in people with HDc. improves physical function and…
a. To establish the effects of (1) body weight support (2) treadmill speed, and (3) level of guidance/ movement support, on the neuromuscular control of the lower extremities in patients with post-stroke hemiparesis, and to determine possible…
The objective of the trial is to assess the safety and tolerability of i.c.v. administration of sNN0029 infusion solution at a dose of 4 µg per day delivered via a Medtronic SynchroMed® II Infusion System.
- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) prevent deterioration of the bladder and renal function?- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) decrease the need for an…
The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…
To investigate the ability of PF-06372865 to demonstrate analgesic properties in healthy subjects for pre-specified primary endpoints using a panel of pain tests.
Primary ObjectivesTo evaluate the safety and efficacy of 2 fixed doses of EVP-6124 hydrochloride (HCl) ( 2 or 3 mg daily) compared to placebo for 26 weeks in subjects with mild to moderate dementia due to Alzheimer*s disease (AD) currently receiving…
With this study we aim to investigate the emotional development, behavior, social behavior, variation in personality traits and intellectual functioning in a group of children who are diagnosed with narcolepsy with of without cataplexie, according…
Primary Objective:- To evaluate the efficacy of PF-04360365 (ponezumab) in subjects with probableCAA as compared to placebo on a BOLD fMRI measure of cerebrovascularreactivity.Secondary Objectives:- To evaluate the efficacy of PF-04360365 (ponezumab…
Primary Objective is to determine whether (A) patients with dystonia(plus) syndromes exhibit more psychiatric symptoms compared to a healthy control group and (B) whether dystonia patients show an altered serotonin metabolism (serotonin transporter…