149 results
1) elucidate the role of the postural CO decrease on cerebral hemodynamics, 2) test the influence of posture, ageing and T2DM on the CO-VO2 relationship. Furthermore, 3) we want to determine the shape of the CO-VO2 relationship.
Primary: to determine whether an early psychological intervention poststroke in order to reduce symptoms of anxiety and depression, is feasible.Secondary: To evaluate if an early individual psychological intervention in patients independent in…
The general aim of this project is to evaluate the effectiveness, safety and costs of a medication withdrawal policy compared to usual care in general practice in patients who are currently treated for hypertension and/or hypercholesterolemia, but…
The aim of the study is to show safety and effectiveness of the Sapiens electrode in an acute, intra-operative setting.
The first aim of the present study is to examine whether the pain experience in adults with Down syndrome (without dementia) differs from the pain experience in adults without intellectual disability, after correction for mentale age, comorbidity…
In this study we will assess the effect of ARA290 on nerve damage by taking 4 skin bipsies during treatment.
To further investigate the pathogenesis of DCI and its relation to gender, decreased fibrinolysis, increased coagulation, and hormonal factors in order to eventually pave the way for new treatment options.
Search for a relation between the concentration of haloperidol in serum and in liquor in elderly who reached a steady state of haloperidol. Secundairy aim: Cal inter-individual variation in serum and CSF concentrations, at the same dose haloperidol…
Primairy objectivesTo study the pharmacokinetics (plasma and cerebrospinal fluid) of meropenem in infants <= 90 days of postnatal age with probable or confirmed bacterial meningitis (BM); To describe the safety profile of meropenem in the…
The objective of this project is to assess the applicability of [11C]GMOM for in vivo imaging of the NMDA receptor.
The primary goal of this trial is to demonstrate that a physical activity program, which consists of an exercise program and follow-up care, under supervision of a specialized physiotherapist can prevent the frequently observed decline in global…
Assessment of Safety, Tolerability, and Pharmacodynamic Effects of LY2886721 in Patients withMild Cognitive Impairment Due to Alzheimer*s Disease or Mild Alzheimer's Disease
To find a simple test to explain non-responsiveness to sumatriptan in a proportion of patients with migraine.
The objectives of this multi-centre, double-blind, randomized, 2-parallelgroups study are to investigate the efficacy, safety and tolerability of levetiracetam (LEV) monotherapy 15-60mg/kg/day versus valproic acid (VPA) monotherapy 10-40mg/kg/day in…
Primary:- To identify causal genetic variants and proteomes involved in achalasia and to study their relevanceSecundary:- To build-up a large scale harmonized biobank of achalasia patients, based on combining existing and new data from the European…
Primary objective:To show that addition of dead space to low-pressure nCPAP (which is usually not effective but can be relatively well tolerated) makes the therapy effective and diminishes the apnea hypopnea index with >10/hour in patients…
The primary objective is to evaluate the effectivity of frozen gloves during chemotherapy in the prevention of neurotoxicity and thereby the influence on the quality of life in patients treated with oxaliplatin, paclitaxel or docetaxel.
Primary Objective: To examine which subregions of the hippocampal formation on 7 Tesla MRI are most affected in patients with early Alzheimer*s disease compared with older persons with normal cognition. Secondary Objectives:a) To explore risk…
To measure the PK of ARA290 when given in de SQ form
- To investigate the cause of the symptoms patients with a vagus nerve stimulator experience during exercise.- To investigate whether there are changes in EEG during stimulation.