149 results
The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…
To evaluate whether SAH patients treated by state-of-the-art SAH management with additional ultra-early and short term TXA administration have a significantly higher percentage of favourable outcome after six months (score 0-3 on the Modified Rankin…
It is required to compare results from conservative- and surgical treatment in The Netherlands and to perform an economic evaluation in order to evaluate the cost-effectivity of both treatment types. On one hand, surgical treatment seems accompanied…
Primary: to determine whether an early psychological intervention poststroke in order to reduce symptoms of anxiety and depression, is feasible.Secondary: To evaluate if an early individual psychological intervention in patients independent in…
To further investigate the pathogenesis of DCI and its relation to gender, decreased fibrinolysis, increased coagulation, and hormonal factors in order to eventually pave the way for new treatment options.
Search for a relation between the concentration of haloperidol in serum and in liquor in elderly who reached a steady state of haloperidol. Secundairy aim: Cal inter-individual variation in serum and CSF concentrations, at the same dose haloperidol…
Primairy objectivesTo study the pharmacokinetics (plasma and cerebrospinal fluid) of meropenem in infants <= 90 days of postnatal age with probable or confirmed bacterial meningitis (BM); To describe the safety profile of meropenem in the…
The primary goal of this trial is to demonstrate that a physical activity program, which consists of an exercise program and follow-up care, under supervision of a specialized physiotherapist can prevent the frequently observed decline in global…
The current study will focus on the effects of an intensive programme of exposure of prism adaptation (i.e. daily exposure during two weeks) and compare these to sham adaptation.
The objective of this project is to assess the applicability of [11C]GMOM for in vivo imaging of the NMDA receptor.
Assessment of Safety, Tolerability, and Pharmacodynamic Effects of LY2886721 in Patients withMild Cognitive Impairment Due to Alzheimer*s Disease or Mild Alzheimer's Disease
To find a simple test to explain non-responsiveness to sumatriptan in a proportion of patients with migraine.
Our goal is to develop and validate a Movement Diagnostic System (MDS) to accurately locate specific CNS pathological changes in ET, PD-T and DYS, with the use of fMRI and scanner compatible EMG, accelerometry, video, and wrist perturbator.
1. Discribe the normal development of mastication in healthy children aged between 6 and 48 months by using the Mastication Observation and Evaluation (MOE). Which oral motor behaviours occurs?2. Determine the differences in mastication between…
Primary objective: To create diagnostic and treatment tools for navigation ability in stroke patients, that can be used in clinical practice.Secondary objective: To increase knowledge about the cognitive structure and neuroanatomical correlates of…
- To assess the burden of disease of congenital CMV infection in the Netherlands at the age of 5 to 6 years through the assessment of the occurrence of sensorineural hearing loss due to congenital CMV infection.- To establish the burden of disease…
1) elucidate the role of the postural CO decrease on cerebral hemodynamics, 2) test the influence of posture, ageing and T2DM on the CO-VO2 relationship. Furthermore, 3) we want to determine the shape of the CO-VO2 relationship.
The objectives of this multi-centre, double-blind, randomized, 2-parallelgroups study are to investigate the efficacy, safety and tolerability of levetiracetam (LEV) monotherapy 15-60mg/kg/day versus valproic acid (VPA) monotherapy 10-40mg/kg/day in…
Primary objective: to assess cortical activity post stroke in a repetitive way to determine cortical involvement in dedicated motor tasks and to relate cortical activity to clinical outcome prospectively after stroke. Secondary objective: to assess…
Primary:- To identify causal genetic variants and proteomes involved in achalasia and to study their relevanceSecundary:- To build-up a large scale harmonized biobank of achalasia patients, based on combining existing and new data from the European…