175 results
To study the quantitative and qualitative relationship between a heat stimulus and the vasomotor response in healthy subjects and to determine the feasibility of this measurement setup for patients.
Primary objective:Evaluate the effect of two doses versus placebo gantenerumab subcutaneous injections on the change in Clinical Dementia Rating Sum of Boxes scale (CDR SOB), a global measure of cognition and functional capacitySecondary objectives:…
The primary objective of this study is to estimate the effect of endovascular treatment on overall functional outcome after acute ischemic stroke of less than six hour duration, in patients with a symptomatic anterior circulation IAO. The secondary…
The main objective of this prospective population-based study of patients with proximal SMA in the Netherlands is to register SMA patients in the Netherlands in a socalled SMA-database to study prevalence and severity of SMA types 1-4, to perform…
To evaluate the effect of surgical decompression of the nerves in the lower extremities in patients with painful diabetic neuropathy.
To determine the effect of botulinum toxin type A injections in stroke patients with stiff knee gait.
Primary objective: To assess the effect of early treatment with paracetamol in a daily dose of 6 g for three consecutive days in patients with acute stroke and a body temperature of 36.5°C or above on the occurrence of a favorable functional outcome…
Primary objective of the study: 1. To report on the effectmodification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…
The goal of this study is to perform an analysis of the ability of the different combinations of MRI technique/stimulation delivery to measure the cerebrovascular reactivity. In this study only the following stimulations will be used for the…
The main objective of the study is to investigate whether the strong clinical effects of natalizumab in RRMS can be explained by enhanced functional adaptation mechanisms of the brain and whether enhanced functional reorganisation is sustained over…
To investigate whether preventive use of the antibiotic ceftriaxone improves functional health outcomes in patients with stroke by preventing infection. This will be done in a large multi-centre randomized controlled trial. Within this trial we will…
1. To determine the reproducibility and sensitivity of the EC of walking test in boys with DMD, in comparison with the reproducibility and sensitivity of the 6MWT. 2. To evaluate the one-year course of limitations in ambulation among boys with DMD,…
To investigate the outcome after induced hypertension versus no induced hypertension in patients with DCI after aneurysmal SAH.
Primary objective:Are coping style and quality of life different in patients receiving PST from patients receiving standard care after the intervention, after 6 months and after 12 months? Secondary objectives:1. Are amount of health care…
Primairy objective: The primary objective of this study is to get insight in the effect of the multidisciplinary integrated care programme on self-help, social participation and experienced quality of life of elderly stroke patients. And the effect…
The aim of this trial is to determine the effectiveness of an operation (decompressive craniectomy), compared to medical management alone, to treat brain swelling and improve outcome. The results of this trial will better define the indications for…
Primary:Part I:- to determine the effects of gabapentin and remifentanil on the evoked area of hyperalgesia, area of allodynia, pinprick hyperalgesia and background pain using a newly developed HCW sensitization modelPart II: - to determine…
To determine the estimation of prevalence of the primary research parameter for deficits in social cognition; e.g. facial emotion perception, after subarachnoid haemorrhage which has been treated through neurosurgical- (clipping) and/or endovascular…
The purpose of the this study is to evaluate the prognostic capabilities of biomarkers in CSF in patients with SCI.
Aim of the study is to evaluate if the optical tissue stylet technology can discriminate tissues that are relevant to recognize for interventional pain procedures.