164 results
Primary Objective: (1) To study the efficacy of exercise therapy and CBT for reducing fatigue and improving activities and HRQoL in patients with PPS. Secondary Objectives: (2) To identify generic and disease-specific determinants of effects.(3) To…
Primary: - What are the effects of gait training with the gait rehabilitation device LOPES on the quality and ability of walking in chronic stroke patients with a stiff-knee gait?- What are the effects of two different training modes in the gait…
The current study aims to investigate whether neural network characteristics of the brain can predict the frequency and severity of epileptic seizures in brain tumor patients. Our secondary objective is to determine the correlation between seizures…
Primary Objective: Studying the phenomenon of tolerance by evaluating pharmacokinetic- and dynamic parameters, in patients receiving long-term ITB therapy.Secondary Objective(s): 1.To specify the intrathecal pharmacokinetics and -dynamics of…
Study CFTY720D2301E1 is designed to assess the following properties of FTY720 inpatients with relapsing MS:* To evaluate long-term safety and tolerability* To evaluate long-term efficacy
The objectives of this study are to compare the safety and efficacy of 2 annual cycles of intravenous (IV) alemtuzumab to 3-times weekly subcutaneous (SC) interferon beta 1a (Rebif*) in patients with active relapsing-remitting multiple sclerosis (…
The main objective is to examine the effectiveness, the costs and the cost-effectiveness of an integrated *fast track* rehabilitation service for multi-trauma patients (SFTRS) involving dedicated early rehab intervention programs. The SFTRS is…
The primary objective is to evaluate the effectiveness of low-intensity hand rim wheelchair exercise training on physical capacity, daily (wheelchair) functioning, participation and quality of life in people with a spinal cord injury. Furthermore,…
In this study, we will systematically investigate the influence of distractors on target processing in patients with lesions to the frontal, parietal and occipital system. This will be measured by eye movements. Furthermore, prism adaptation will be…
The aim of this study is to develop an immortalised B-cell line derived from MG patients. This antibody producing cell line will be used for different applications:- The establishment of new passive transfer disease models for MG- The identification…
The purpose of this study in patients with primary progressive multiple sclerosis (PPMS) is to evaluatewhether FTY720 is effective in delaying MS disability progression in the absence of relapsescompared to placebo. Furthermore, safety and…
1- to describe the presence and severity of hemiplegic CP on the basis of neonatal MRI findings and correlate the involvement of different structures (basal ganglia, posterior limb of the internal capsule and hemisphere) with the size of the lesion2…
To document the long-term safety and tolerability of teriflunomide in MS patients with relapses.
The primary aim of the proposed study is to assess whether stenting for symptomatic vertebral artery stenosis >= 50% is feasible and safe. A secondary aim is to assess the rate of new vascular events in the territory of the vertebrobasilar…
1. To determine the diagnostic accuracy, in terms of detecting a vascular malformation, of CTA, MRI/MRA, DSA, or combinations thereof in patients with ICH?2. To find out which test or combination of tests is most effective for the detection of…
This project aims to understand the symptomatology PD in the light of functional brain interactions, in the hope of elucidating the role of the frontal striatal system to behaviour.
Aims:a) Understand persistence and/or plasticity of the brain correlatesb) Understand specificity of the brain correlatesQuestions:a) Which neural correlates of OCD are state dependent and thus normalized after successful treatment?b) Which neural…
We want to investigate if it is possible to set up the entire process of home mechanical ventilation outside the hospital. This means practically that the patients will not be admitted to the hospital. The goal of this study is to answer the…
EXPLICIT aims tot obtain better functional outcome by early intensive rehabilitation. Next to clinical tests to measure improvement in function, neuroplasticity is assessed by fMRI, TMS and haptic robots. The combination of clinical outcome measures…
To find out if cervical TENS affects cerebral bloodflow as measured with transcranial doppler sonography in healthy subjects, and to find a dose-response relation for this effect. To find out if cervical TENS can suppress sympathetic tone as…