2114 results
The primary objective of this study is to evaluate the effect of surgical correction of pes equinovarus deformity compared to conservative treatment on personalized goal attainment. In addition, we will evaluate the effect of surgical correction of…
It is hypothesized that bCBT for severe fatigue will lead to clinical improvements in fatigue levels compared to usual care.
This study will investigate the potential value of CFX treatment, by prospective monitoring of functioning in patients that undergo this treatment. Likewise, aspects of the treatment that are important for patient experience will be systematically…
The study will address the feasibility of the shared decision-making (SDM) intervention by (1) analysing the acceptability of the intervention by users (i.e. professionals and patients); (2) assessing the level of implementation; (3) testing…
Continuous Intrajejunal Levodopa Infusion is not cost-effective compared to Deep Brain Stimulation
Both interventions (GRAIL training & endurance and strength training (control intervention)) will result in an increase in gait speed, functional walking ability and social participation. However, the GRAIL training will result in larger…
1. Discribe the normal development of mastication in healthy children aged between 6 and 48 months by using the Mastication Observation and Evaluation (MOE). Which oral motor behaviours occurs?2. Determine the differences in mastication between…
Primary: Safety and tolerability of fingolimod 0,5 mg in a broader population of MS patients.Explorerend: incidence of macular edema, bradyarrythmia, Patient-Reported Outcomes Indices for Multiple Sclerosis (PRIMuS) and Short Form Health Survey*12 (…
Study cortical involvement in motor control using system identification techniques in the time and frequency domain.
PrimaryTo investigate the inter-rater and intra-rater variability of a novel neurophysiological measurement (Motor Unit Number Index, MUNIX) for estimation of functioning motor units, in healthy controls and ALS patientsSecondaryTo evaluate the…
Primairy objective:• To determine the safety, tolerability and pharmacokinetics of 2B3-201, and in comparison to free methylprednisolone hemisuccinate and placebo;Secundairy objective:• To determine the pharmacodynamic effects of 2B3-201 on CNS…
The main objective is to evaluate the effect of the modified Atkins diet on the seizure frequency of institutionalized adults with refractory epilepsy and severe intellectual disability.
- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) prevent deterioration of the bladder and renal function?- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) decrease the need for an…
The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…
Our objective is to perturb neural activity in the parietal-occipital cortex in PD patients (and age-matched control subjects) to determine if the activity contributes to better visually-guided behaviour, but at the same time, to diminished…
The aim of the study is to determine whether prenatal and current exposure to environmental chemicals is associated with developmental outcome in adolescents. We will investigate whether this exposure is associated with the thyroid hormone…
the main objective of this study is to evaluate the ability and reproducibility of high-resolution 3 Tesla MR imaging to visualise intracranial arteries and intracranial atherosclerotic disease in patients with previous TIA or ischemic stroke.
The main goal of this study is to investigate the side effects of deep brain stimulation in Parkinson's disease. An important aspect of these side effects is the reward-oriented behavior. For this reason, patients will be administered…
Immune regulation by dimethylfumarate (DMF) in patients with relapsing Remitting Multiple Sclerosis.
Primary objective: * Increases treatment with DMF the ability of Tregs to inhibit in relapsing-remitting MS patients? Proliferation of conventional T cells * Provides treatment with DMF to an increase in the number of nTreg (Foxp3 expression) or…
Objective:The aim of this project is to apply motor-cognitive-mental elements together for psychiatric diagnosis, treatment, and prevention. We will examine and quantify the diagnostic value of motor-cognitive-mental elements in predicting (a)…