37 results
there exist intra & inter patient variability of 17β-HSD-1 and other enzymes involved in the local generation of estrogens
To answer the question if dried blood spot (DBS) analysis and saliva hormone testing are reliable methods to determine the concentration of NGF-ß in healthy subjects.
To induce a vaccine specific immune response, hereby we hope to introduce the possibility of a new treatment to improve patient outcome and survival.
The objective of this study is to obtain preliminary data on variability in PSMA expression by comparing the tracer uptake on conventional clinical 68Ga-PSMA PET/CT with an additional 68Ga-PSMA PET/CT (4 weeks later) within primary prostate cancer…
To determine whether cine-MRI is able to assess the so-called *sliding viscera* sign in the posterior compartment, an known sonographic indicator for the absence of POD adhesions.
To characterize the exposure-response relationship of MVT-602 effects on luteinizing hormone (LH) concentrations after subcutaneous administration of single 0.1 to 3 µg doses of MVT-602 or placebo in healthy premenopausal women undergoing COS to…
To explore the relationship between hormone levels and HRQoL in patients with TS and KS.
Primary objective: To determine the efficacy of the combination of olaparib and abiraterone vs placebo and abiraterone by assessment of rPFS (Radiographic progression-free survival) in patients with mCRPC (Metastatic castration-resistant prostate…
Assessment of disease control, and genito-urinary and rectal side effects, in patients with localized prostate cancer, 24 months after focal IRE therapy.
The aim of this study is to assess the relationship between the AGD, the 2D:4D ratio and the presence of MRKH syndrome, endometriosis and PCOS.
The main goal of this technical feasibility study is to investigate with which HPV isolation and detection method urine and the Evalyn Brush can be combined. HPV stability in urine and on the Evalyn Brush will be investigated as it*s unclear how…
The objective of this study is to statistically identify the optimal level of contact-pressure for DBT. *Optimal* is defined as a weighed sum of three clinical interests: as high as possible lesion conspicuity, as low as possible absorbed glandular…
To compare the effects of LNG-IUD (Mirena® of Kyleena®) versus Cu-IUD (T-Safe® or Multi-Safe®) on mental well-being and quality of life.
To assess toxicity of MRI-guided focal salvage high-dose-rate brachytherapy (HDR-BT) in patients with locally recurrent prostate cancer. Secondary objectives are quality of life, biochemical disease free survival, dose restrictions, technical…
The primary aim of this first line 177Lu-PSMA RLT study is to evaluate the clinical efficacy in castration resistant metastatic prostate cancer. Secondary aims are to assess the progression free survival (radiographic, clinical or PSA progression…
The primary objective of this study is to compare overall survival (OS) in patients with progressive PSMA-positive mCRPC who receive 177Lu-PSMA-617 in addition to best supportive/best standard of care versus patients treated with best supportive/…
primary objective:To evaluate the effect of individualised FE 999049 treatment on ovarian response in a long GnRH agonist protocol versus a GnRH antagonist protocolSecondary objectives:* To evaluate the effect of individualised FE 999049 treatment…
The purpose of this study is to understand if a new treatment for prostate cancer (niraparib) added to a standard treatment (abiraterone acetate plus prednisone) will work better than the standard treatment alone.Cohort 3: the purpose is to evaluate…
Primary Objective• To compare the progression free survival (PFS) of programmed death-ligand 1 (PD-L1) positive patients with Stage III or IV high-grade nonmucinous epithelial ovarian cancer treated with platinum-based combination therapy,…
The OPTIMUM-study aims to gain insight into the optimal timing and method for promoting sustained adherence to lifestyle and body weight recommendations in PMBC survivors.The aim of the extra measurement during the second COVID-19 lockdown is to…