175 results
To test the technical performance of the monitoring and feedback tool in a *real life* situation. To test the usability, acceptance and user satisfaction of the tool. To test how care givers (practice nurses and general practitioners) and patients…
The objective of this study is to investigate:1) the prevalence of insomnia in patients with T2D with and without depression2) whether insomnia in patients with T2D with and without depression, is associated with increased levens of HbA1C3) whether…
We propose to perform a pilot study to examine the feasibility of studying the triangular association between: 1) amino acid metabolism (influenced by, amongst other factors, diet composition [e.g. energy intake, macronutrient intake, individual…
Primary objective:To observe the effect of gastric bypass surgery on household members and partners who live together with the patient on body mass index (measured as weight/height²) in the first year following bariatric surgery compared to family…
The main objective is to optimize the supplementation of vitamins and minerals to prevent postoperative deficiencies after MB / RYGB or GS on the long term. We also examined whether the number of outpatient visits, blood tests, and costs can be…
To examine whether heating can prevent the hyperglycaemia-induced decline in endothelial function in T2DM and age- and sex-matched controls.
To obtain values for lipid profile (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides) and markers for insulin sensitivity (insulin, glucose, HbA1c) in 3- to 5-year-old children.
To describe the differences in macrophage infiltration and mRNA expression of adipocytokines in subcutaneous, omental and perirenal fat tissue in Cushing's syndrome compared to healthy controls.
Primary objective:- To obtain reference values for arterial stiffness, measured as PWV and AIx, and insulin resistance, calculated as HOMA-IR in normal weight, healthy adolescents in different Tanner stages.Secondary objectives: - To determine the…
The research aims to identify avoidable and non-preventable factors, which contribute to the development of chronic tophaceous gout. In addition, the study aims to assess the consequences (quality of life, comorbidity) of tophi.
The primary objectives are defined according to a hierarchical design: i) to tailor and apply multi-parametric, functional MRI techniques to identify cerebral abnormalities (cerebral biomarkers) in DM2 and MetS; ii) to investigate which cerebral…
The primary aim of this study is to assess the impact of prolonged walking on fluid- and electrolyte balance in 32 patients with T2DM, compared with a matched group of 32 healthy control subjects, and 32 patients with T1DM, during the Nijmegen Four…
Investigate the degree of association between the level of AGE*s and the development and progression of paratonia in Alzheimer*s Disease (AD).Research questions are:(1) Are elevated levels of AGE*s, at baseline and during 12 months follow-up,…
Are AGEs, as a predictor of increased risk for cardiometabolic syndrome, increased in shift workers?
The aim of this study is to investigate skin AGEs, as a predictor of increased risk for cardiometabolic syndrome, in a shift work population as compared to non-shift workers to assess its potential as an early assessment of the actual risk for…
The objective of this study is to assess the diagmostic accuracy of microMRI to detect ROD in children with ESRD and metabolic bone disease by oxalosis in patients suffering from oxalosis.
The purpose of this study is to evaluate the safety, accuracy and performance of the Symphony CGM System in patients admitted to the Intensive Care Unit (ICU). The Symphony CGM system will be evaluated for 24 hours in ICU patients who meet the…
This study aims to assess the degree of accuracy of test weighing in order to determine whether or not test weighing is a useful method in clinical practice.
The first objective is to examine the impact of 4-month walking training on physical fitness, insulin resistance and cardiovascular risks in T2DM and their controls and to assess whether these effects are preserved 3 months after cessation of the…
The aim of this study is to evaluate compliance with two different ONS formats in hospitalised geriatric patients with (or at risk of) malnutrition.
1) Determine whether humanized mice develop enhanced restenosis upon vascular injury after reconstitution with human PBMCs derived from T2DM subjects with or without macrovascular disease.2) Determine what mechanism(s) induces deranged vascular…