122 results
The STEM study presented here aims to increase our knowledge of the most common intestinal, gastric and liver epithelial diseases with the ultimate goal to treat these disorders. Particularly, children that have severe malfunction of their…
Primary Objective: To study effects of RWPs on insulin sensitivity, glucose tolerance, microvascular function (skin and muscle), insulin-mediated microvascular responsiveness, and blood pressure.Secondary objectives: To study effects of RWPs on…
The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…
The objective of the study is to gain insight in the role of endogenous GLP-1 on food-stimuli related CNS satiety and reward responses and the alterations between lean and obese-T2DM individuals. Also, to gain information about treatment with a GLP-…
Primary objective: To evaluate the insulin sensitivity measured with Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) in obese children and adolescents 3 years after diagnosis of insulin resistance.Secondary objectives:1. To evaluate the…
Primary objectiveTo measure the conversion rate of mono- and disaccharides into oligosaccharides and mannitol in the digestive tract by the action of food grade micro-organisms Secondary objectivesTo measure pH of gastric and duodenal fluids at…
Primary Objective: To assess immediate and long-term effects of Mindfulness-based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) in reducing depressive symptoms in patients with diabetes. Regarding immediate effects, we expect that…
We propose a 2-week randomized controlled, single-blinded pilot study to compare the health effects of a Paleolithic diet and an isocaloric reference diet (based on the *Guidelines for a healthy diet 2006*) on markers of the MetS which are risk…
The goal of this study is to investigate the feasibility of distant, internet-based follow-up and monitoring of the weigth of 20 gastric bypass patients. Our research results will determine whether or not the use of the Youw8 weight scale is…
The primary objective of this study is to evaluate tolerance of a new high-energy high-protein oral nutritional supplement compared to a commercially available high-energy high-protein oral nutritional supplement in elderly subjects in need of oral…
The objective of the study is to compare the effects of homogenized, unhomogenized and skimmed milk with butter on postprandial metabolism in healthy overweight men.
To determine the effect of hypoglycaemia on BAT-activity.
We will investigate endothelial function before and after bariatric surgery.
To determine the safety and efficacy (in increasing insulin sensitivity) of TRC 150094 once daily dosing for 4 weeks in male subjects with increased cardiometabolic risk.To evaluate the effect of TRC150094 on hepatic fat and metabolic parameters.To…
The aim of the study is to quantify the requirement of threonine in preterm infants. We hypothesize that the current estimations for preterms are too high.
To set up NQplus, a longitudinal observational study on 1750 members of the sampling frame to a. build NDARD, the National Dietary Assessment Reference Databaseb. build a database to validate the LifeLines FFQc. build a database and biobank for the…
The effect of radiotherapy on glucose metabolism in patients with rectal cancer; a feasibility study
Primary objective:Effect of preoperative radiotherapy on insulin resistance in rectal cancer patients.Secondary objectives:Effect of preoperative radiotherapy on plasma oxidative stress parameters.
To investigate the time difference between the blood glucose excursion and the subsequent appearance of cerebral 13C glucose after intravenous glucose loading.
Primary Objective: - HSPG expression in liver tissue of patients with type 2 diabetes mellitus and NASH compared to liver tissue from subjects without type 2 diabetes mellitus with and without NASH. Secondary Objectives: - Correlation between HSPG…
Effects of stearidonic acid on serum triacylglycerol concentrations in overweight and obese subjects
To study the effects of echium oil, rich in SDA on serum triacylglycerol concentrations in healthy overweight and slightly obese men and women. The minor objective is to study the effects of echium oil on the omega-3 index, which is negatively…