123 results
Primary Objectives: - DirectLifeDirectLifeAre the LiveWorkout® and DirectLife® concept feasible web based training programs for type 2 diabetes patients ?- How do type 2 diabetes patients experience web based training intervention programs ? What…
To demonstrate differences in neuronal structure and neuronal function in brain regions that control eating behaviour between obese and normal weight adolescents.
To evaluate the effect of surgical decompression of the nerves in the lower extremities in patients with painful diabetic neuropathy.
Primary objective: to compare glucose profiles collected by CGM on days with and without haemodialysis in a group of insulin treated diabetic patients who are on regular hemodialysis treatment. Secondary objectives: o assessment of frequency and…
To assess the effects of a 4-week high protein diet on body composition in obese children. Secondary outcomes are whole-body protein turnover, gluconeogenesis, energy expenditure, markers of the metabolic syndrome, appetite sensations,…
* To evaluate the long-term efficacy of FCM (using targeted ferritin levels to determine dosing) or oral iron to delay and/or reduce erythropoiesis stimulating agent (ESA) use and/or other anaemia management options in NDD-CKD subjects with iron…
To determine non inferiority of two doses of BI 10773 (10 mg/daily and 25 mg/daily) compared to placebo with respect to first occurrence of any of the adjudicated components of the primary composite Major Adverse Cardiovascular Event endpoint (…
The primary objective of this phase III study is to demonstrate that lixisenatide can reduce cardiovascularmorbidity and mortality (composite endpoint of cardiovascular (CV) death, non-fatal myocardialinfarction (MI), non-fatal stroke,…
The objective of the current study is to investigate the efficacy, safety and tolerability of BI10773 (25mg once daily) compared to glimepriride (1-4mg daily) given for 104 weeks with a 104-week extention period in patients with type 2 diabetes…
Driven by the hypothesis that combination of dietary polyphenols, with distinct mechanisms of action, may improve cellular energy and fatty acid metabolism, preventing thereby the development of the metabolic syndrome and diabetes, the following…
The current research proposal aims to investigate the medium and long-term health benefits of a combined supervised exercise and dietary intervention versus a dietary intervention (=usual care) in obese long-standing type 2 diabetes patients. It is…
The objective of this study is to evaluate the effects of resveratrol on apo A-I concentrations in subjects with low serum HDL-cholesterol (HDL-c) concentrations at baseline. Minor objectives are to study the effects of resveratrol in the same…
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
To investigate whether an exercise-program that takes the patient*s level of exercise-self-efficacy into account, added to regular care, is more effective compared to regular care in increase the patients level of physical activity, improve…
Primary:to assess the reduction of initial study drug Cmax after administration of 20 mg study drug 10% SRF using three modified formulations as compared to the current Phase 3 formulation in healthy volunteers.Secondary:to assess the safety and…
The main purpose of this pilot study is to evaluate the safety of the PANDIT system by testing the system in a group of patients, under strict supervision of a diabetes nurse. The main objective is to check whether PANDIT provides correct insulin…
The objective of the current study is to investigate the efficacy, safety and tolerability of linagliptin (5 mg / once daily) compared to placebo given for 24 weeks as add-on therapy to stable treatment in elderly patients with diabetes mellitus…
1. To compare the effects of fasting on energy sensing machinery in muscle of obese vs normal weight subjects2. To compare neuronal activity in the brain in response to fasting in obese vs normal weight humans3. To compare the activity of the HPA…
The primary objective of the study is to compare the absorption of MK-7 after intake of 3 different MK-7 supplements.
To asses whether the success of protein diets is related to predisposition of overweight and sensitivity for food-reward