122 results
To evaluate the effect of cholecalciferol supplection on the systolic blood pressure in hypertensive patients with a 25-hydroxycholecalciferol insufficiency. Secondly, the effects on PRA, aldosteron, 25-hydroxycholecalciferol, alkaline phosphatase,…
In this study, we want to investigate whether obese children perform differently than normal weight children (data already generated) on tasks of sensitivity to reward and executive functioning.
The aim of the current study is to get insight into the in potential lifelong consequences of active disease and or prednisone use during pregnancy on the children of women with rheumatoid arthritis. As readout it uses indicators (risk factors) for…
In this RCT we combine cognitive behavioural therapy (CBT) with a maintenance contract and a specific diet (very low calorie diet), to obtain and maintain favourable effects on weight and risk profile over the long term.
In addition to our current research in type 2 diabetes patients on oral blood glucose lowering medication, we would like to assess the glucoregulatory effects of different exercise modalities in the impaired glucose tolerant (pre-diabetes) state and…
In subjects with T2DM, with inadequate glycemic control, who have a history or high risk of CV disease:Primary Objectives*to assess the effect of canagliflozin plus standard of care relative to placebo plus standard of care on CV risk as measured by…
The objective of this observational, randomized study is to examine the efficacy, safety and patient acceptance of the basal plus insulin regimen (i.e. one injection rapid acting insulin glulisine at the main meal added to once daily basal insulin…
The current proposal studies the efficacy of a multifactorial intervention with weight reduction, behavioural therapy, and physical exercise on the severity and control of overweight/obese children with asthma. Also the underlying mechanism of these…
To determine the relationship between pericoronary adipose tissue (dys)function, in terms of the cytokine and adipokine secretion profile and histologic markers of inflammation, and coronary atherosclerosis.
Is addition of a DPP4-inhibitor (vildagliptin) beneficial in type 2 diabetic patients, starting on once daily long-acting insulin in combination with 2 dd metformin. Primary end point is necessary dose of insulin to remain glycemic control.…
Study 11. To determine whether or not there are differences, at baseline, in mTOR activity, between Caucasians and Hindostani, 18-25 years old and healthy on the one hand and middle-aged (40-50 years) with abdominal adiposity on the other hand2. To…
Primary Objectives * To assess the efficacy of rosuvastatin in paediatric patients with familial hypercholesterolaemia. * To establish long-term safety, tolerability and efficacy of rosuvastatin in paediatric patients with familial…
Primary: To measure the effect of a high protein diet on whole body protein synthesis and -breakdown, as well as on net whole body protein balance and production of urea in children after cardiac surgerySecondary: To measure the effect of a high…
1. Does mPAT directly impair vasoreactivity to insulin and acetylcholine ex vivo in arterioles obtained from muscle biopsy in lean and obese individuals?2. Is obesity in humans associated with the accumulation of mPAT and an inflammatory mPAT…
Investigate the effect of adjuvant metformin therapy on insulin need and on glycaemic control in CFRD patients.
To evaluate if the program *Run2gether* can change physical behavior in children with obesity and/or diabetes, and thereby increase physical fitness level and insulin sensitivity en reduce body weight. An additional goal for children with diabetes,…
OBJECTIVESPrimary ObjectiveThe primary objective is to evaluate the efficacy, safety, and tolerability of 800 and 1,200 mg/day of carisbamate compared with placebo in reducing the average daily pain in subjects with diabetic peripheral neuropathy (…
In this study the effects of a two-week moderately intense-intense physical activity on vascular function, glucose-metabolism, lipid-metabolism and adipose tissue function will be analyzed.
The aim of the study is twofold. The first is the impact of DRL-21994 and the registered product on the release of vessels studied and compared. The second is the speed with which DRL-21994 is included in the body examined, as well as the degree of…
Assessment of the effect of kidney-pancreas transplantation in diabetic nephropathy patients on microvascular alterations using orthogonal spectral polarization and correlate this effect with markers for endothelial cell dysfunction and fibrosis