249 results
We aim to study the effectiveness of an intervention provided by nurse practitioners who will:- Provide conversations on Advance care planning (ACP);- Coordinate care based on patients needs at advanced stage;
Primary ObjectivesAssess whether the finger tapping task endpoints:• Differentiate between ON and OFF states in PD patients• Correlate with the MDS-UPDRS part III total score• Differentiate between placebo and levodopa/carbidopa treatmentSecondary…
The main objective of this study is to evaluate the effect of the dynamic shoulder orthosis on the shoulder pain and glenohumeral subluxation.
The primary objective of this study is:* To evaluate the effect of filgotinib compared to placebo in active psoriatic arthritis (PsA) as assessed by the American College of Rheumatology 20% improvement (ACR20) response at Week 12Secondary objectives…
The primary objective is to study the association between maternal TL and the risk of SB in offspring. The secondary objectives are to investigate the relation between maternal TL and obstetrical (pregnancy course and outcome), environmental risk…
Primary objective: To determine diaphragm thickness and thickening fraction in healthy children below or equal to 8 years of age.Secondary objective: To determine the interrater reliability of operators performing the ultra-sound
The primary objective of this study is to evaluate the long-term safety and tolerability of OV101 in individuals with AS assessed by the incidence and severity of AEs and SAEs in subjects who are at least 2 years old.The secondary objectives of this…
The main objective of the study is to investigate MEG-based hippocampal and whole brain neuronal hyperactivity in preclinical DIAD mutation carriers and to find proof-of-concept for the translatability of findings from preclinical AD mouse models to…
Primary objective: To evaluate the long-term safety and tolerability of BIIB078 in participants with C9ORF72-ALS.Secondary objective: To evaluate the PK of BIIB078 in participants with C9ORF72-ALS.Exploratory objectives:- To evaluate the PD of…
The objective of this study is:- to estimate the electrical conductivity of the chronic stroke lesion and the variance on this within chronic stroke subjectsSecondary:- derive functional organisation of the motor system of the upper extremity…
INCbase is a research platform to collect prospective standardized longitudinal data from a worldwide population of patients with suspected CIDP. One of the first objectives of the Inflammatory Neuropathy Consortium Base (INCbase) is to develop a…
To validate SAI as a measure for cholinergic innervation by relating SAI directly to [18F]FEOBV PET imaging. The secundary aims are as follows: - To assess the correlation between SAI and cognitive functioning, motor symptoms, RBD, walking speed,…
The primary objective is generation of functional neuronal networks from induced pluripotent stem cells (iPSCs) derived from patients with ischemic stroke. The secondary objectives are to measure neuronal network responses to simulated cerebral…
The aim of the current study is to determine whether a *liberal* strategy of maintaining Hb concentrations above 9 g/dL would result in a different neurological outcome when compared to a *restrictive* approach to red-cell transfusion to avoid…
Our key objective of this study is to elucidate potential peripheral and central mechanisms that determine chronic pain characteristics in humans with OA.
The main objective of the study is to explore the bone remodeling in order to examine long-term stability of the implant after 10 years follow-up.
PRIMARY OBJECTIVE To characterize the pharmacokinetics (PK) of single doses of solriamfetolin pediatric subjects with narcolepsy.SECONDARY OBJECTIVE To assess the safety and tolerability of single doses of solriamfetol inpediatric subjects with…
The primary objective of the study is to monitor the effectiveness of the NEMOST Growing Domino to correct the scoliotic curve in growing patients suffering from progressive adolescent idiopathic scoliosis who have failed conservative treatment.
To assess the efficacy of add-on high-dose simvastatin on markers for disease progression in MS patients treated with natalizumab or ocrelizumab for at least six months.
The primary objective is to evaluate whether the concentration of six biomarkers (proteins) in SDH are related to the time of incidence of TBI. The secondary objective is to evaluate whether the fractions of the Hb-derivatives in SDH are related to…