157 results
The primary objective of the proposed study is to investigate whether bumetanide therapy indeed reduces autistic symptomatology. Important secondary goals of this project are to determine whether bumetanide will improve specific behavioral,…
The proposed study aims to bring neuroimaging and genetics closer to the child/adolescent psychiatric clinic by developing automated classifiers, and obtain associated multimodal biomarker profiles. Such biomarkers are prospected to, aid in clinical…
Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…
The proposed experimental pilot study focuses on harm reduction in a specific subpopulation, i.e. in patients with schizophrenia (long-term psychotic disorder) with a suboptimal response to the currently available interventions, smoking a lot of…
To assess in paediatric patients with ASD with and without (first-time) antipsychotic medication• the prevalence and incidence of insulin resistance and other metabolic abnormalities• the risk factors for insulin resistance and other metabolic…
The primary objectives are (1) to investigate the feasibility of online courses targeting nutrition and food-related behaviour and (2) to investigate whether the feasibility of the online courses is related to depressive symptoms. The secondary…
Our primary objective is to evaluate the effectiveness of mindfulness training in improving self-control of youth with ADHD. As secondary objectives, we aim to quantify the effectiveness in reducing ADHD symptoms, reducing comorbid (e.g. ASD)…
Primary Objective: The main objective is to investigate the effectiveness of PRT compared to CAU in school-aged children and adolescents with ASD.The primary research question is:1) Directly after treatment and at follow-up, what is the…
Primary ObjectiveEstimate the proportion of subjects fulfilling criteria for symptomatic remission (as defined by Andreasen et al.)* following a transition to 12 months* treatment with flexible-dose PP3M in subjects with schizophrenia previously…
To systematically unravel the complex victimhood of refugee mothers and their children, and to discern whether children born from sexual violence face even greater challenges. This information will be used to develop resources for professionals…
To investigate whether bright light therapy is an effective treatment for depression during pregnancy compared with low-intensity placebo light therapy (proof-of-principle) and to investigate the late effects of bright light therapy versus placebo…
Primary ObjectiveIn preparation for a multicentre RCT we want to test the VR SCT for people with psychotic disorders in a feasibility study. We want to evaluate the feasibility and acceptability of VR SCT and improve the intervention protocol using…
We aim to validate MRS with a cholinergic challenge as method to investigate muscarinic M1 receptor functioning. To investigate the relationship between the response to a muscarinic receptor antagonist with biperiden phMRI and [123I]IDEX SPECT…
Studies examining the effect of couple therapy or couple-based interventions in treatment for personality disorder are very scarce and more research is required. Therefore, the present study examines the effect of couple-based interventions in…
The primary goal is to evaluate the effectiveness of a screening and prevention program for adolescents who experience depressive symptoms. The secondary goal is to find factors which possibly relate to the effectiveness of the prevention program.…
1) Can changes in functional brain networks in patients with and without hallucinations from several psychiatric, neurological, and perceptual disorders be detected? And if so, what is the pattern of change in these diseases?2) Are specific changes…
This study attempts to explore the relation between the functioning of the schema-related mPFC, REM sleep and affective memory bias, by simulating a depressive-like state in healthy subjects through negative mood induction and applying rTMS to…
If the hypotheses of this study are confirmed, this might have important implications for the allocation of patients to group or individual treatments. As it is expected that patients with limited mental flexibility and empathy experience less group…
To develop a 360o video VR relaxation program (VRelax) for reducing impact of stress in patients with depressive, anxiety and psychotic disorders. Feasibility, user-friendliness and immediate effects on subjective and objective stress reactivity…
In this study, we want to assess the variability and the causality between hormonal changes and aggressive behaviour within a psychotic patient, an anti-social personality disordered patient, an anti-social personality disordered patient with a PCL-…