31 results
Systems biology is an interdisciplinary approach that systematically describes the complex interactions between all the parts in a biological system, with a view to elucidating new biological rules capable of predicting the behavior of the…
To monitor the effect of the free plate technique in Baerveldt implant surgery on the postoperative eye motility.
Primary: to compare the treatment effect of ranibizumab PRN (visual acuity loss and/or SD-OCT disease activity guided retreatment) versus aflibercept bimonthly regimen on central retinal thickness stability as measured by mean fluctuations between…
To visualize the different components of RAP lesions with high resolution Doppler OCT, and to evaluate the change in intra- and transretinal flow after treatment.
EFFICACY OBJECTIVESThe primary efficacy objective of this study is to evaluate the efficacy of intravitreal injections of 10 mg lampalizumab administered Q4W or Q6W in CFI profile biomarker positive and CFI profile biomarker-negative patients…
The objective of this study is to observe the anatomical and functional outcomes of ocriplasmin over a 6-month follow-up period.
EFFICACY OBJECTIVESThe primary efficacy objective of this study is to evaluate the efficacy of intravitreal injections of 10 mg lampalizumab administered Q4W or Q6W in CFI profile biomarker positive and CFI profile biomarker-negative patients…
The objective of this study is to investigate the use of retinal oximetry in children, between five and seventeen years of age, with (vitreo-) retinopathies and oxygen-related diseases of the retina by means of an Oxymap T1 fundus camera.
To investigate whether oral administration of dabigatran etexilate in patients with a rhegmatogenous retinal detachment leads to clinical significant dabigatran levels and thrombin inhibiting activity in the vitreous and subretinal fluid.
To assess whether there is a change in visual function and status of the retina after a year of intervention in subjects with early signs of Age-related Macular Degeneration.
The primary objective is to investigate the efficacy, safety and tolerability of RV 001 (a fully human anti-IGF-1R antibody) administered q3W for 6 months, in comparison to placebo, in the treatment of patients suffering from active TED.Secondary…
The objective of this study is to determine the optimal background light intensity for the examination of the visual field with a perimetry test and to confirm the de Vries-Rose, Weber's and Ferry-Porters law in patients with glaucoma.
To demonstrate equivalence for ECD between Topcon SP-1P Specular microscope and Nidek Confoscan 4.
To demonstrate that DMEK is superior to DSAEK with respect to VA.
To compare the severity of retinopathy of prematurity (ROP) among treated infants with an untreated control population, matched for GA at birth while confirming the dose of rhIGF 1/rhIGFBP-3 is safe and efficacious.
To determine the effect of tube position in the anterior chamber on the corneal endothelium.
To study neuronal and ophthalmological characteristics of a newly detected clinical entity called slow vision which hampers visual perception and attention of the affected patients.
Identification of the proteins that are involved in neurite outgrowth in PDR. We want to determine what protein levels are increased in the vitreous by local production and which RNA transcripts are present in the fibrotic membranes of patients with…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic HCHWA-D disease carriers, in order to find a *biomarker* for disease stage and progression.
The purpose of the study is to investigate the safety and effectiveness of the HF IF PIOL, and to compare performance with the Artiflex lens. Study outcomes will be used to obtain CE marking for the lens and for registration and marketing purposes.