43 results
To assess accuracy of 18F-sodiumfluoride (NaF) positron emission tomography (PET) and serum non-oxidized parathyroid hormone (PTH) as an accurate, reliable and easy applicable diagnostic tools for the assessment of bone turnover in chronic kidney…
To study the clinical value of pressure and flow assessment for predicting treatment response to PTRA and validate the pressure gradient assessment by CFD in patients with available CT angiography.
1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…
Investigate the effects of 7 (+-1) days of of mono- and combination therapy with the SGLT2 inhibitor empagliflozin (10 mg QD) and RAS inhibitor losartan (50 mg QD) on renal hemodynamics, (glomerular filtration rate (GFR) / effective renal plasma…
1) To isolate and cryopreserve human primary bladder muscle and urothelial cells from women with isolated UUI so that we can validate the results from the molecular landscape in vitro.2) To collect and store human bladder biopsy tissues from women…
To determine the effect of salt (NaCl) supplementation on (1) physiological parameters (such as serum potassium) and on (2) clinical signs and symptoms and quality of life.
ObjectivesPrimary* To evaluate the efficacy of mirabegron in children (5 to < 18 years of age) with OABSecondary* To evaluate the efficacy of mirabegron in children (5 to < 18 years of age) with OAB* To evaluate the safety and…
We aim to investigate the renal hemodynamic effects of empagliflozin in people with either preserved or impaired renal function with T2DM and people with impaired renal function without T2DM, all with and without adenosine blockade.
The main goal of this study is to assess whether CUDI-quantification of CEUS can successfully be correlated to malignant pathology results of kidney tissue.
To evaluate the efficacy of BAY 2327949 to decrease urine albumin-to-creatinine ratio (UACR) in patients with chronic kidney disease.To evaluate the safety and tolerability of BAY 2327949.
Primary objective:To evaluate the safety and tolerability of a single dose of DCR-PHXC in patients with PH3Secondary objectives:To characterize the plasma PK of a single dose of DCR-PHXC in patients with PH3To assess the efficacy of a single dose of…
To demonstrate the effect of salt and/or protein intake on aquaresis in patients with ADPKD who are treated with a vasopressin V2 receptor antagonist as measured by 24-hour urine volume.
The main objectives are:• To assess canagliflozin target (i.e. receptor) specific binding in vivo• To assess receptor occupancy of canagliflozin in vivo• To determine optimal scanning time in vivoTo explore the relationship between canagliflozin…
To assess whether a complete pathological respons (cPR) after neo-adjuvant chemotherapy can be predicted based on clinical, radiological, and histological variables and on a wide set of tissue and blood/urine (liquid biopsy) biomarkers (DNA/RNA).…
Investigation of maintenance of erectile function after MR-guided radiotherapy with neurovascular sparing in patients with localized prostate cancer.
- To evaluate the effect of magnesium and phosphate supplementation on intracellular levels of magnesium and phosphate determined with different techniques.- To determine if symptoms are related to intracellular levels of magnesium or phosphate.
The primary objective is to study whether muscle mass, muscle strength and self-reported physical health differ between patients on conventional hemodialysis and those on nocturnal hemodialysis. The second objective is to evaluate whether muscle…
Determine the feasibility, safety and efficacy of electromagnetic-based image guided navigation system during soft tissue (robot assisted) laparoscopic surgery.
Primary: To determine the individual response to the SGTL2 inhibitor dapagliflozin in urine albumin-to-creatinine ratio (UACR) Secondary:- To determine the individual response to the SGLT2 inhibitor dapagliflozin in: - Systolic blood pressure - Body…
To compare belzutifan+lenvatinib to cabozantinib with respect to PFS per Response Criteria in Solid Tumors (RECIST) 1.1 as assessedby blinded independent central review (BICR).