24 results
The aim of this research is to gain a more detailed insight into the illness perceptions of patients with lung cancer. With this insight it is our aim to improve biopsychosocial care for these patients. Research question: What are the illness…
The objective of this study proposal is to investigate whether use of biomarkers (intracellular pemetrexed levels and/or geneticloci) for response and toxicity to pemetrexed improves the effectiveness of therapy and cost-effectiveness ratio. This…
To investigate the dynamics of tumour hypoxia as assessed by 18F-FAZA PET/CT during and after chemoradiotherapy. To investigate the best strategy to deliver a boost dose to the hypoxic tumour areas. This strategy may be either a simultaneous boost (…
To investigate the newly developed method to study lung density changes using CT-scan, in a small patient population. The relationship between radiation induced lung density changes and dose distribution/tumor location will be investigated.
The primary objective is to evaluate the percentage of the study population who have OSAS before and after treatment and the severity of it. A second objective is to correlate the prevalence of OSAS with different tumour sites and stages, as well as…
The main objective of the study is to monitor the factors effecting success of PDT, namely oxygen, photosensitizer concentration and, light dose before and during illumination to gather data that can be clinically correlated and later implemented.
The goal of this study is to investigate the feasibility of the integration of an EMTS in a standard clinical EUS setting.
The main aim of this study is to explore the recovery of physical and psychological health status, and HRQoL simultaneously in lung cancer patients that have undergone lung resection in the Netherlands. Next to that, we hope to identify the…
This Phase II trial aims to:1 Test the predictive value of Zr89 Cetuximab uptake in vivo for treatment specific outcome 2 Explore the impact of dose redistribution on loco-regional control and disease free survival.If individualized treatment…
2.1 Primary objectives Primary objective is scientific research to study the additional effect of bevacizumab on hypoxia related parameters. 2.2 Secondary objectives a) To compare the efficacy of bevacizumab with pre-treatment obtained values of…
To explore the influence of psychological factors - e.g. causal attribution, religiosity, mindfulness, Type D personality, benefit finding, and optimism - on survival, fatigue, depression, and health-related quality of life of stage IIIb/IV…
The objective of the study is a prospective study to evaluate which type of TE shunt prosthesis is the most cost-effective.
To study the diagnostic accuracy of FDG PET and MRI as a function of time in the response monitoring and detection of residual lymph node metastases after non-surgical treatment of advanced head and neck cancer.
The hypothesis investigated is that a correct diagnosis (including subclassification of the tumor) and prognosis can be made more rapidly and that monitoring tumor development in response to therapy is more precise when adding tumor markers to the…
Mortality will be lower in patients who do not smoke during treatment of non-small cell lung carcinoma with PD-L1-inhibitors compared to patients who smoke during their treatment with PD-L1-inhibitors.
The aim of the study is to create and optimize a DWI MRI scan protocol to assess thymic masses.
In this study, the agreement between liquid biopsy and tissue biopsy based KRAS/EGFR molecular diagnostics will be determined. Additionally, pairwise comparison of different liquid biopsy based molecular tests will be performed based on several…
To examine the goals of patients and doctors for treatment with chemotherapy, immunotherapy or targeted therapy in metastatic lung cancer and whether these goals are achieved according to patients, doctors and relatives.
The primary goal of this study is to gain insight changes in components of nutritional status and functional capacity over time.The objective is to improve the multidisciplinary health care for lung cancer patients.Secundary goals are to investigate…
The primary objective is 1) to describe the long-term course of QoL in HNC patients and their informal caregivers and to identify cancer-related, personal, genetic, biological, psychobehavioural, physical, lifestyle-related, and social determinants…