179 results
Objective:The aim of our study is to obtain a collection of head and neck squamous cell carcinomas that is well characterized for relevant clinical parameters, including follow-up.
primary aim of the study To investigate the efficacy of PEP-223/CoVaccine HT in decreasing serum testosterone levels to below castrate levels, i.e. to < 2 nmol/l, within 8 weeks after the last of three injectionssecondary aims of the studyTo…
Primary objective:To compare the immunological response to vaccination with HPV16 E6 and E7 synthetic long peptides with concomitant application of imiquimod at the vaccination site with vaccination without the concomitant application of imiquimod.…
The purpose of this phase I/II is to characterize the safety, tolerability, preliminary activity, pharmacokinetic (PK) and pharmacodynamics (PD) profile of TKI258 administered orally on a 5 days on/2 days off dosing schedule in adult patients with…
To evaluate the efficacy of the dose level/regimen(s) of RAD001recommended from the phase I with HT therapy. This will bebased on the evaluation of overall response rate according toRECIST [Post-Text Supplement 1].
The objective of this study is to determine the accuracy of the sentinel lymph node biopsy in multicentric breast cancer prospectively and multi-institutional.
The proposed project aims at implementing the available scientific knowledge for recommending biopsies or active treatment, respectively, at the individual level in Dutch urological practice. To this end we have developed an internet based decision…
To determine whether SRT achieves a local control rate comparable to surgery in patients with metastatic lung disease.
The current study aims to investigate whether neural network characteristics of the brain can predict the frequency and severity of epileptic seizures in brain tumor patients. Our secondary objective is to determine the correlation between seizures…
Primary:- Can carboplatin exposure in children be predicted by taking the plasma concentrations of creatinine of cystatine C into account?Secundary:- Which is the effective carboplatin exposure in the current pediatric treatment protocols?- Is there…
Primary:To determine the response rate and response quality of dasatinib monotherapy or dasatinib/fludarabine combination in fludarabine refractory CLL patientsSecundaryTo asses the overall safety profile of this treatment approachTo asses event…
To determine the safety and toxicity of administration of HA-1 peptide vaccine in HLA-A2 and HA-1 positive patients who had undergone allogeneic stem cell transplantation from a HLA-A2 positive, HA-1 negative donor.To evaluate whether an immunologic…
Objective of this study is to determine the efficacy of midostaurin in patients with ASM or MCL with/without an associated hematological clonal non-mast cell lineage disease.
To investigate the efficacy and safety of BIBF 1120 as compared to placebo in patients with stage IIIB/IV or recurrent non small cell lung cancer treated with standard therapy of pemetrexed after failure of first line chemotherapy.
To assess the feasibility and efficacy of 90Y-ibritumomab tiuxetan consolidation treatment after R-PECC chemotherapy as second or third line treatment in patients with refractory or relapsed aggressive B-cell NHL, after or not eligible for…
This phase I study aims to define the MTD of the combination of cisplatin/hyperthermia/lapatinib, to confirm that the 2 agents combined with hyperthermia can be administered safely, and to recommend a dose for further clinical studies.
to evaluate the role of thoracic irradiation in patients with ED-SCLC who respond to chemotherapy and to assess the effect on 1 year survival
To investigate prospectively how the "TAMRO-profile" performs in a pre-operative treatment setting. In addition we can examine whether the profile is specific for tamoxifen or is predictive for endocrine resistance in general. Also the…