466 results
The aim of this study is to assess the change of ammonia exhaled in Helicobacter pylori (HP) positive patients compared with patients that are not HP infected after urea administration. In principle, in this pilot study, the results of Kearney et al…
We propose to perform a pilot study to examine the feasibility of studying the triangular association between: 1) amino acid metabolism (influenced by, amongst other factors, diet composition [e.g. energy intake, macronutrient intake, individual…
To examine cellular damage, intestinal barrier function loss, activation of the Complement system and inflammatory alterations induced by ischemia and reperfusion of the human small and large intestine.Second, we aim to study the consequences of…
1. Primary objective:To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in subjects aged 18 years and older with chronic non-cancer pain, suffering from OIC.2. Secondary objectives:To assess the safety and…
Primary objective: to investigate the intra- and interfraction motility of the CTV (the primary tumor as well as any affected celiac lymph nodes) in radiotherapy for esophageal cancer, and to determine adequate CTV-ITV margins.Secondary objective:…
To compare accuracy, patient experience and costs of lower gastrointestinal endoscopy (sigmoidoscopy and colonoscopy) between nurse and physician endoscopists.
To assess the involvement of a specific genetic risk allele on oxidative stress induced by neutrophils in relation to H. pylori infection.
1) To investigate what changes are present in skeletal muscle tissue of elderly gastric and colonic cancer patients (>80) compared with younger gastric and colonic cancer patients (<60) and compared to elderly controls and younger…
Implementation of a biobank infrastructure to facilitate development and improvement of screening markers for colorectal neoplasia. New biomarkers will be compared to state of the art tests, e.g. currently FIT.
The aim of this study is to find a succesful treatment for functional abdominal pain in children and at the same time improve the quality of life of these children. A second aim is to reduce the hospital visits and with that the costs.
Primary objective of this study is the identification of familial germline mutations in SPS. Secondary objectives are to get a better insight in the molecular pathway of SPS and associated colorectal carcinoma, to discriminate those family members…
The primary objective of the study is to evaluate the safety of a high IV iron dosing regimen of iron iso-maltoside 1000 in subjects with IDA secondary to IBD. The secondary objectives of the study are: · To evaluate the efficacy of a high IV iron…
Aim: To investigate the performance of the new ESPGHAN diagnostic criteria for celiac disease in practice in different European countries.Primary aim: To evaluate whether the omission of biopsies in selected pediatric cases does result in certain…
Identifying subsets of Crohn's disease (CD) at risk for poor outcomes is a priority in pediatric CD research. Having the ability to predict patients more likely to relapse, to be refractory to therapy or to develop complications may enable…
Primary Objective:- To determine the incidence of EPI in pancreatic cancer.Secondary Objectives are: 1. To identify the predictive factors for the development of EPI in pancreatic cancer.2. To evaluate the occurrence of nutritional deficiencies in…
- Primary Objective: to investigate whether the administration of a small amount of dobutamine postoperatively is able to positively influence the sublingual microcirculation in patients who are undergoing esophagectomy.- Secondary Objective: to…
Primary: to analyze serum samples of adult EoE patients for IgE reactivity to recombinant allergens of common foods.Secondary: to demonstrate the presence of ILC2 in periferal blood of adult patients with eosinophilic esophagitis Tertiary: To store…
Primary ObjectiveThe primary objective of this study will be to compare the efficacy of infliximab with that of placebo in the prevention of clinical recurrence of CD through Week 76, defined as a composite endpoint that requires endoscopic…
The primary objective is to evaluate the presence of inflammation in the mucosa around diverticula in the sigmoid colon in patients without clinical symptoms of diverticular disease and without endoscopic evidence of inflammation. This is compared…
In the Netherlands, gum chewing has not been incorporated in the standard postoperative care after intra-abdominal surgery. Therefore a multi-center RCT was set up to evaluate the influence of gum chewing on the development of ileus. Our null…