75 results
We hypothesize that benesco TM reduces symptoms, esophageal acid sensitivity and permeability in patients with reflux symptoms
Does Mindfulness-Based Cognitive Therapy (MBCT) reduce psychological distress and improve sleep quality and quality of life compared to treatment as usual (TAU) in patients with IBD?
The objective of this study is to assess the safety and feasibility of WATS for esophageal sampling after nCRT in patient with esophageal cancer.
To test the first feasibility and safety of intratumoral 166-holmium microspheres implantation in pancreatic cancer in a controlled, open-surgery setting.
Primary Objective: To investigate the efficacy and safety of octreotide treatment (a somatostatin analogue) in decreasing the transfusion requirements (IV iron infusions and / or red blood cell transfusions) in patients with GI bleeding caused by…
The objective of this study is to confirm procedural performance of the Exalt single-use duodenoscope in Endoscopic Retrograde Cholangiopancreatography (ERCP) or other duodenoscope-based procedures.
1. To validate the existing guidelines with prospective and retrospective data from this cohort by performing an upper endoscopy at baseline, one year after inclusion and subsequently every three years thereafter in order to assess the risk of…
- Primary Objective:To evaluate the safety and tolerability of investigational regimens of sotorasib in adult subjects with KRAS p.G12C mutant advanced solid tumors- Secondary Objectives:To characterize PK of product(s) used in investigational…
To assess the effect of citalopram on symptoms of chest pain in patients with functional chest pain.
We aim to estimate the sensitivity and specificity of the CELTiC panel in FIT-positive populations.
The aim of this study is to investigate the efficacy of subcutaneous IFX in the treatment of moderate to severe Crohn*s disease with and without concomitant immunosuppression, as measured by the proportion of patients in corticosteroid-free clinical…
The overall objective of this study is to determine whether the use of additional Lapvas-imaging derived visual feedback might influence the choice of surgeons for the optimal location of the anastomosis.
In the present study, we propose to explore whether a Systems Medicine approach can identify biomarkers that predict the clinical outcome in patients with Crohn*s disease in whom vedolizumab is started.
Primary objective:to investigate and compare the effect of EUS-GE and SGJ on patients* short- and long-term ability to eat* (time to oral intake, and reinterventions for persistent or recurrent symptoms of GOO within 6 months of follow-up,…
To investigate the mechanism of fatigue and inflammation in IBD using clinical biomarkers, transcriptomic and epigenetic sequencing, and an innovative health patch.
The main objective of this study is to investigate the migratory behaviour of neutrophils isolated from healthy individuals and gluten-related disease patients* blood to develop a diagnostic tool for gluten-related diseases that can replace biopsy…
To provide an extensive clinical and psychosocial characterization of IBS patients with and without psychological and/or physical comorbidities, as well as of disease-controls without IBS, but with psychological and/or physical disease, and a…
The main aim is to investigate the effect of a dietary intervention on CD patients and healthy volunteers. The dietary interventions consist of the Groningen anti-inflammatory diet (GrAID) and a vitamin B2/B3/C supplement (ColoVit) and they will be…
To compare the efficacy of POEM to the efficacy of endoscopic pneumodilatation as initial treatment of symptomatic idiopathic achalasia in children. The primary outcome measure is the need of retreatment (i.e. EBD, LHM, POEM or intra-sphincteric…
This Phase Ia/Ib study will evaluate the safety, pharmacokinetics, immunogenicity (as applicable for study biotherapeutics), preliminary activity, and biomarkers of GDC-6036 as a single agent (Arm A) and in combination with other anti-cancer…